PMID- 15483339
OWN - NLM
STAT- MEDLINE
DCOM- 20050307
LR  - 20181113
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 19
IP  - 5
DP  - 2004 Oct
TI  - Genistein supplementation inhibits atherosclerosis with stabilization of the 
      lesions in hypercholesterolemic rabbits.
PG  - 656-61
AB  - The effect of genistein on aortic atherosclerosis was studied by 
      immunohistochemistry with RAM-11 and HHF-35 antibodies and western blotting for 
      matrix metalloproteinase-3 (MMP-3) in New Zealand White rabbits. After 
      provocation of atherosclerosis with hyperlipidemic diet, the rabbits were divided 
      as hyperlipidemic diet group (HD), normal diet group (ND) and hyperlipidemic plus 
      genistein diet group (HD+genistein) for 4 and half months. The average cross 
      sectional area of atherosclerotic lesion was 0.269 mm2 after provocation. The 
      lesion was progressed by continuous hyperlipidemic diet (10.06 mm2) but was 
      increased mildly by genistein (0.997 mm2), and decreased by normal diet (0.228 
      mm2). The ratio of macrophages to smooth muscle cells in the lesion was not 
      changed by genistein supplementation. The western blotting showed reduction of 
      MMP-3 expression in HD+genistein and ND groups than HD group. The inhibition of 
      atherogenesis by genistein was might be due to improve the endothelial 
      dysfunction rather than direct action on macrophages and/or smooth muscle cells 
      in the lesion, since endothelial dysfunction by lipid peroxidation was the main 
      atherogenic factor in the hypercholesterolemic rabbits. The genistein 
      supplementation also suggests that it helps the stabilization of the 
      atherosclerotic lesion by inhibition of MMP-3 expression.
FAU - Lee, Choong-Sik
AU  - Lee CS
AD  - Department of Pathology, Chungnam National University College of Medicine, 
      Daejeon, Korea. cslee@cnu.ac.kr.
FAU - Kwon, Su-Jin
AU  - Kwon SJ
FAU - Na, Sun-Young
AU  - Na SY
FAU - Lim, Seung-Pyung
AU  - Lim SP
FAU - Lee, Jung-Hee
AU  - Lee JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Growth Inhibitors)
RN  - DH2M523P0H (Genistein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Aorta/pathology
MH  - Arteriosclerosis/*drug therapy/pathology/*prevention & control
MH  - Blotting, Western
MH  - Diet, Atherogenic
MH  - Genistein/*pharmacology
MH  - Growth Inhibitors/*pharmacology
MH  - Hypercholesterolemia/*drug therapy/pathology
MH  - Macrophages/pathology
MH  - Male
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Muscle, Smooth, Vascular/enzymology/pathology
MH  - Rabbits
PMC - PMC2816326
EDAT- 2004/10/16 09:00
MHDA- 2005/03/08 09:00
PMCR- 2004/10/01
CRDT- 2004/10/16 09:00
PHST- 2004/10/16 09:00 [pubmed]
PHST- 2005/03/08 09:00 [medline]
PHST- 2004/10/16 09:00 [entrez]
PHST- 2004/10/01 00:00 [pmc-release]
AID - 200410656 [pii]
AID - 10.3346/jkms.2004.19.5.656 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2004 Oct;19(5):656-61. doi: 10.3346/jkms.2004.19.5.656.