PMID- 15485859
OWN - NLM
STAT- MEDLINE
DCOM- 20050204
LR  - 20210206
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 279
IP  - 51
DP  - 2004 Dec 17
TI  - Role of tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) in 
      distinct and overlapping CD40 and TNF receptor 2/CD120b-mediated B lymphocyte 
      activation.
PG  - 53222-31
AB  - Members of the tumor necrosis factor receptor (TNFR) family play a variety of 
      roles in the regulation of lymphocyte activation. An important TNFR family member 
      for B cell activation is CD40. CD40 signals stimulate B cell TNF-alpha secretion, 
      which subsequently signals via TNFR2 (CD120b) to enhance B cell activation. 
      Although the function of the pro-apoptotic and pro-inflammatory receptor TNFR1 
      (CD120a) has been the subject of much research, less is understood about the 
      distinct contributions of CD120b to cell activation and how it stimulates 
      downstream events. Members of the tumor necrosis factor receptor family bind 
      various members of the cytoplasmic adapter protein family, the tumor necrosis 
      factor receptor-associated factors (TRAFs), during signaling. Both CD40 and 
      CD120b bind TNF receptor-associated factor 2 (TRAF2) upon ligand stimulation. 
      Wild type and TRAF2-deficient B cells expressing CD40 or the hybrid molecule 
      (human) CD40 (mouse)-CD120b were examined. CD40- and CD120b-mediated IgM 
      secretion were partly TRAF2-dependent, but only CD40 required TRAF2 for c-Jun 
      N-terminal kinase activation. CD40 and CD120b used primarily divergent mechanisms 
      to activate NF-kappaB, exemplifying how TNFR family members can use diverse 
      mechanisms to mediate similar downstream events.
FAU - Munroe, Melissa E
AU  - Munroe ME
AD  - Department of Microbiology, The University of Iowa and Veterans Affairs Medical 
      Center, Iowa City, IA 52242, USA.
FAU - Bishop, Gail A
AU  - Bishop GA
LA  - eng
GR  - AI07260/AI/NIAID NIH HHS/United States
GR  - AI07343/AI/NIAID NIH HHS/United States
GR  - AI28847/AI/NIAID NIH HHS/United States
GR  - AI49993/AI/NIAID NIH HHS/United States
GR  - CA099997/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20041012
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Antibodies)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (CD40 Antigens)
RN  - 0 (Detergents)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Ligands)
RN  - 0 (NF-kappa B)
RN  - 0 (NF-kappa B p52 Subunit)
RN  - 0 (PSIP1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Psip1 protein, mouse)
RN  - 0 (RELB protein, human)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Relb protein, mouse)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 147337-75-5 (Transcription Factor RelB)
RN  - EC 1.13.12.- (Luciferases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 4)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - Active Transport, Cell Nucleus
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Antibodies/chemistry
MH  - Antibodies, Monoclonal/chemistry
MH  - Apoptosis
MH  - B-Lymphocytes/*metabolism
MH  - CD40 Antigens/*biosynthesis
MH  - Cell Line
MH  - Cytoplasm/metabolism
MH  - Detergents/pharmacology
MH  - Enzyme Activation
MH  - Humans
MH  - Immunoglobulin M/chemistry
MH  - JNK Mitogen-Activated Protein Kinases/metabolism
MH  - Kinetics
MH  - Ligands
MH  - Luciferases/metabolism
MH  - Lymphocyte Activation
MH  - MAP Kinase Kinase 4
MH  - Mice
MH  - Mitogen-Activated Protein Kinase Kinases/metabolism
MH  - Models, Biological
MH  - NF-kappa B/metabolism
MH  - NF-kappa B p52 Subunit
MH  - Phosphorylation
MH  - Protein Binding
MH  - Protein Structure, Tertiary
MH  - Proto-Oncogene Proteins/metabolism
MH  - Receptors, Tumor Necrosis Factor, Type II/*biosynthesis
MH  - Signal Transduction
MH  - TNF Receptor-Associated Factor 2/*metabolism
MH  - Time Factors
MH  - Trans-Activators/metabolism
MH  - Transcription Factor RelB
MH  - Transcription Factors/metabolism
MH  - Transcriptional Activation
MH  - Transfection
EDAT- 2004/10/16 09:00
MHDA- 2005/02/05 09:00
CRDT- 2004/10/16 09:00
PHST- 2004/10/16 09:00 [pubmed]
PHST- 2005/02/05 09:00 [medline]
PHST- 2004/10/16 09:00 [entrez]
AID - S0021-9258(18)81960-3 [pii]
AID - 10.1074/jbc.M410539200 [doi]
PST - ppublish
SO  - J Biol Chem. 2004 Dec 17;279(51):53222-31. doi: 10.1074/jbc.M410539200. Epub 2004 
      Oct 12.