PMID- 15488792
OWN - NLM
STAT- MEDLINE
DCOM- 20041115
LR  - 20111117
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 138
IP  - 4
DP  - 2004 Oct
TI  - Human leukocyte antigen A29 subtypes associated with birdshot 
      retinochoroidopathy.
PG  - 631-4
AB  - PURPOSE: To determine whether birdshot retinochoroidopathy is associated with 
      subtypes of the human leukocyte antigen (HLA)-A29 other than HLA-A*2902. DESIGN: 
      Experimental study. METHODS: High-resolution DNA typing of HLA-A29 subtypes was 
      performed on blood from 20 subjects with birdshot retinochoroidopathy using 
      polymerase chain reaction-based typing methods. Results were compared with 
      published controls. RESULTS: Four of 20 subjects (20%) had the HLA-A*2901 allele; 
      two were homozygous for HLA-A*29, and both had the HLA-A*2901 and HLA-A*2902 
      alleles. Among 18 subjects with only one HLA-A*29 allele, the HLA-A*2902 allele 
      was found in 16 (89%) and the HLA-A*2901 allele was found in two (11%). No 
      subject was found to have HLA-A*2903, HLA-A*2904, HLA-A*2905, or HLA-A*2906. 
      CONCLUSIONS: Both HLA-A*2901 and HLA-A*2902 are associated with birdshot 
      retinochoroidopathy. Our data do not support the previous suggestion that the 
      HLA-A29.1 serotype may be protective against development of birdshot 
      retinochoroidopathy. Additional studies will be required to determine whether the 
      other, less common subtypes are associated with the disease. HLA-A29 subtype 
      testing is not required for the clinical evaluation of HLA-A29-positive patients 
      with birdshot retinochoroidopathy.
FAU - Levinson, Ralph D
AU  - Levinson RD
AD  - Ocular InflammatoryDisease Center and Department of Ophthalmology, Jules Stein 
      Eye Institute, Los Angeles, California 90095-7002, USA. levinson@jsei.ucla.edu 
      <levinson@jsei.ucla.edu>
FAU - Rajalingam, Raja
AU  - Rajalingam R
FAU - Park, Min S
AU  - Park MS
FAU - Reed, Elaine F
AU  - Reed EF
FAU - Gjertson, David W
AU  - Gjertson DW
FAU - Kappel, Peter J
AU  - Kappel PJ
FAU - See, Robert F
AU  - See RF
FAU - Rao, Narsing A
AU  - Rao NA
FAU - Holland, Gary N
AU  - Holland GN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A29 antigen)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Chorioretinitis/*genetics
MH  - DNA/analysis
MH  - DNA Fingerprinting
MH  - Gene Frequency
MH  - HLA-A Antigens/*genetics
MH  - Humans
MH  - Polymerase Chain Reaction
EDAT- 2004/10/19 09:00
MHDA- 2004/11/16 09:00
CRDT- 2004/10/19 09:00
PHST- 2004/06/03 00:00 [accepted]
PHST- 2004/10/19 09:00 [pubmed]
PHST- 2004/11/16 09:00 [medline]
PHST- 2004/10/19 09:00 [entrez]
AID - S0002-9394(04)00672-5 [pii]
AID - 10.1016/j.ajo.2004.06.016 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2004 Oct;138(4):631-4. doi: 10.1016/j.ajo.2004.06.016.