PMID- 15489105
OWN - NLM
STAT- MEDLINE
DCOM- 20041130
LR  - 20071115
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 44
IP  - 8
DP  - 2004 Oct 19
TI  - Transplantation of progenitor cells and regeneration enhancement in acute 
      myocardial infarction: final one-year results of the TOPCARE-AMI Trial.
PG  - 1690-9
AB  - OBJECTIVES: The Transplantation of Progenitor Cells And Regeneration Enhancement 
      in Acute Myocardial Infarction (TOPCARE-AMI) trial investigates both safety, 
      feasibility, and potential effects on parameters of myocardial function of 
      intracoronary infusion of either circulating progenitor cells (CPC) or bone 
      marrow-derived progenitor cells (BMC) in patients with acute myocardial 
      infarction (AMI). BACKGROUND: In animal experiments, therapy with adult 
      progenitor cells was shown to improve vascularization, left ventricular (LV) 
      remodeling, and contractility after AMI. METHODS: A total of 59 patients with AMI 
      were randomly assigned to receive either CPC (n = 30) or BMC (n = 29) into the 
      infarct artery at 4.9 +/- 1.5 days after AMI. RESULTS: Intracoronary progenitor 
      cell application did not incur any measurable ischemic myocardial damage, but one 
      patient experienced distal embolization before cell therapy. During hospital 
      follow-up, one patient in each cell group developed myocardial infarction; one of 
      these patients died of cardiogenic shock. No further cardiovascular events, 
      including ventricular arrhythmias or syncope, occurred during one-year follow-up. 
      By quantitative LV angiography at four months, LV ejection fraction (EF) 
      significantly increased (50 +/- 10% to 58 +/- 10%; p < 0.001), and end-systolic 
      volumes significantly decreased (54 +/- 19 ml to 44 +/- 20 ml; p < 0.001), 
      without differences between the two cell groups. Contrast-enhanced magnetic 
      resonance imaging after one year revealed an increased EF (p < 0.001), reduced 
      infarct size (p < 0.001), and absence of reactive hypertrophy, suggesting 
      functional regeneration of the infarcted ventricles. CONCLUSIONS: Intracoronary 
      infusion of progenitor cells (either BMC or CPC) is safe and feasible in patients 
      after AMI successfully revascularized by stent implantation. Both the excellent 
      safety profile and the observed favorable effects on LV remodeling, provide the 
      rationale for larger randomized double-blind trials.
FAU - Schachinger, Volker
AU  - Schachinger V
AD  - Department of Cardiology, Johann Wolfgang Goethe-University Frankfurt, 
      Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.
FAU - Assmus, Birgit
AU  - Assmus B
FAU - Britten, Martina B
AU  - Britten MB
FAU - Honold, Jorg
AU  - Honold J
FAU - Lehmann, Ralf
AU  - Lehmann R
FAU - Teupe, Claudius
AU  - Teupe C
FAU - Abolmaali, Nasreddin D
AU  - Abolmaali ND
FAU - Vogl, Thomas J
AU  - Vogl TJ
FAU - Hofmann, Wolf-Karsten
AU  - Hofmann WK
FAU - Martin, Hans
AU  - Martin H
FAU - Dimmeler, Stefanie
AU  - Dimmeler S
FAU - Zeiher, Andreas M
AU  - Zeiher AM
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Bone Marrow Transplantation
MH  - Coronary Circulation/physiology
MH  - Feasibility Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Ventricles/physiopathology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/physiology
MH  - Myocardial Infarction/mortality/physiopathology/*surgery
MH  - Pilot Projects
MH  - Postoperative Complications/mortality
MH  - Regeneration/physiology
MH  - Shock, Cardiogenic/mortality
MH  - Ventricular Remodeling/physiology
EDAT- 2004/10/19 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/10/19 09:00
PHST- 2004/06/08 00:00 [received]
PHST- 2004/06/24 00:00 [revised]
PHST- 2004/08/02 00:00 [accepted]
PHST- 2004/10/19 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/10/19 09:00 [entrez]
AID - S0735-1097(04)01629-8 [pii]
AID - 10.1016/j.jacc.2004.08.014 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2004 Oct 19;44(8):1690-9. doi: 10.1016/j.jacc.2004.08.014.