PMID- 15491286
OWN - NLM
STAT- MEDLINE
DCOM- 20041217
LR  - 20061115
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 127
IP  - 3
DP  - 2004 Nov
TI  - Multiple myeloma involving central nervous system: high frequency of chromosome 
      17p13.1 (p53) deletions.
PG  - 280-4
AB  - Central nervous system (CNS) involvement is an unusual manifestation in multiple 
      myeloma (MM). The molecular basis of CNS myeloma is poorly understood. MM is 
      characterized by translocations involving the immunoglobulin heavy chain (IgH) 
      locus and frequent 13q deletions. Alterations of p53 or c-myc in MM may represent 
      secondary changes associated with disease progression. We investigated nine 
      patients with CNS MM using interphase fluorescence in situ hybridization (FISH) 
      combined with immunofluorescence detection of the cytoplasmic light chain 
      (cIg-FISH) for the presence of above genomic aberrations. Of nine patients 
      studied, eight cases had hemizygous p53 deletion and 4 had 13q deletions. Of the 
      patients with 13q deletions, two had IgH translocations, one involving 4p16.3 
      (FGFR3), the other involving 16q23 (c-maf). The high incidence of p53 deletions 
      detected by cIg-FISH in CNS myeloma may be a marker for chromosomal instability, 
      and may be associated with metastatic features of myeloma cells.
FAU - Chang, Hong
AU  - Chang H
AD  - Department of Laboratory Hematology, Princess Margaret Hospital, University 
      Health Network, University of Toronto, Toronto, ON, Canada. hong.chang@uhn.on.ca
FAU - Sloan, Stephen
AU  - Sloan S
FAU - Li, Dan
AU  - Li D
FAU - Keith Stewart, A
AU  - Keith Stewart A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Central Nervous System Neoplasms/*genetics
MH  - *Chromosomes, Human, Pair 17
MH  - Female
MH  - Gene Deletion
MH  - *Genes, p53
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics
MH  - Prognosis
EDAT- 2004/10/20 09:00
MHDA- 2004/12/18 09:00
CRDT- 2004/10/20 09:00
PHST- 2004/10/20 09:00 [pubmed]
PHST- 2004/12/18 09:00 [medline]
PHST- 2004/10/20 09:00 [entrez]
AID - BJH5199 [pii]
AID - 10.1111/j.1365-2141.2004.05199.x [doi]
PST - ppublish
SO  - Br J Haematol. 2004 Nov;127(3):280-4. doi: 10.1111/j.1365-2141.2004.05199.x.