PMID- 15492231
OWN - NLM
STAT- MEDLINE
DCOM- 20041203
LR  - 20231213
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 64
IP  - 20
DP  - 2004 Oct 15
TI  - The gap junction protein connexin32 is a mouse lung tumor suppressor.
PG  - 7191-6
AB  - Although loss of connexin expression and/or gap junction intercellular 
      communication correlates with decreased growth control and increased neoplastic 
      potential, there is limited evidence directly linking gap junction intercellular 
      communication function with tumor suppression in situ. Here, we show for the 
      first time that a gap junction protein, connexin32 (Cx32), acts as a lung tumor 
      suppressor in a mouse model. Cx32-deficient nontumorous lung tissue exhibited an 
      increased proliferative index (P < 0.001), and, after exposure to the carcinogen 
      diethylnitrosamine, Cx32-deficient mice exhibited a highly statistically 
      significant (P < 0.001) increase in bronchioloalveolar lung tumor incidence (28 
      of 45, 62%) and a 45% increase in average multiplicity compared with wild-type 
      mice (7 of 29, 24%). Tumors from Cx32-deficient mice also showed increased 
      activation of mitogen-activated protein kinase (P < 0.001) compared with 
      wild-type tumors, implicating this signaling pathway in Cx32/gap junction 
      intercellular communication-associated lung tumorigenesis.
FAU - King, Timothy J
AU  - King TJ
AD  - Cancer Prevention Research Program, Public Health Sciences Division, Fred 
      Hutchinson Cancer Research Center, and Department of Pathobiology, University of 
      Washington, Seattle, Washington, USA. tking@fhcrc.org
FAU - Lampe, Paul D
AU  - Lampe PD
LA  - eng
GR  - R01 GM055632/GM/NIGMS NIH HHS/United States
GR  - AR47963/AR/NIAMS NIH HHS/United States
GR  - GM55632/GM/NIGMS NIH HHS/United States
GR  - T32-AI07509/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Connexins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Peptides)
RN  - 0 (Pulmonary Surfactant-Associated Protein C)
RN  - 0 (Sftpc protein, mouse)
RN  - 3IQ78TTX1A (Diethylnitrosamine)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Bromodeoxyuridine/metabolism
MH  - Connexins/*deficiency/physiology
MH  - Diethylnitrosamine
MH  - Disease Models, Animal
MH  - Enzyme Activation
MH  - Female
MH  - Gap Junctions/physiology
MH  - Intercellular Signaling Peptides and Proteins
MH  - Lung Neoplasms/chemically induced/metabolism/*pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Peptides/metabolism
MH  - Pulmonary Surfactant-Associated Protein C
MH  - Gap Junction beta-1 Protein
EDAT- 2004/10/20 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/10/20 09:00
PHST- 2004/10/20 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/10/20 09:00 [entrez]
AID - 64/20/7191 [pii]
AID - 10.1158/0008-5472.CAN-04-0624 [doi]
PST - ppublish
SO  - Cancer Res. 2004 Oct 15;64(20):7191-6. doi: 10.1158/0008-5472.CAN-04-0624.