PMID- 15492556
OWN - NLM
STAT- MEDLINE
DCOM- 20041123
LR  - 20240510
IS  - 0003-4932 (Print)
IS  - 1528-1140 (Electronic)
IS  - 0003-4932 (Linking)
VI  - 240
IP  - 5
DP  - 2004 Nov
TI  - Resolved and unresolved controversies in the surgical management of patients with 
      Zollinger-Ellison syndrome.
PG  - 757-73
AB  - OBJECTIVE: Highlight unresolved controversies in the management of 
      Zollinger-Ellison syndrome (ZES). SUMMARY BACKGROUND DATA: Recent studies have 
      resolved some of the previous controversies including the surgical cure rate in 
      patients with and without Multiple Endocrine Neoplasia-type1 (MEN1), the 
      biological behavior of duodenal and pancreatic gastrinomas, role of imaging 
      studies to localize tumor, and gastrectomy to manage acid output. METHODS: Review 
      of the literature based on computer searches in Index Medicus, Pubmed and Ovid. 
      RESULTS: Current controversies as identified in the literature include the role 
      of endoscopic ultrasound (EUS), surgery in ZES patients with MEN1, 
      pancreaticoduodenectomy (Whipple procedure), lymph node primary gastrinoma, 
      parietal cell vagotomy, reoperation and surgery for metastatic tumor, and the use 
      of minimally invasive surgical techniques to localize and remove gastrinoma. 
      CONCLUSIONS: It is hoped that future studies will focus on these issues to 
      improve the surgical management of ZES patients.
FAU - Norton, Jeffrey A
AU  - Norton JA
AD  - Department of Surgery, Stanford University Medical Center, Stanford, California 
      94305-5641, USA. janorton@stanford.edu
FAU - Jensen, Robert T
AU  - Jensen RT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann Surg
JT  - Annals of surgery
JID - 0372354
SB  - IM
MH  - Duodenal Neoplasms/diagnosis
MH  - Endosonography
MH  - Gastrectomy
MH  - Gastrinoma/diagnosis
MH  - Humans
MH  - Laparoscopy
MH  - Lymph Node Excision
MH  - Multiple Endocrine Neoplasia Type 1/complications
MH  - Pancreatic Neoplasms/diagnosis
MH  - Pancreaticoduodenectomy
MH  - Stomach Neoplasms/diagnosis/surgery
MH  - Treatment Outcome
MH  - Vagotomy, Proximal Gastric
MH  - Zollinger-Ellison Syndrome/complications/diagnosis/*surgery
PMC - PMC1356480
EDAT- 2004/10/20 09:00
MHDA- 2004/12/16 09:00
PMCR- 2005/05/01
CRDT- 2004/10/20 09:00
PHST- 2004/10/20 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/10/20 09:00 [entrez]
PHST- 2005/05/01 00:00 [pmc-release]
AID - 00000658-200411000-00006 [pii]
AID - 0000658-200411000-00006 [pii]
AID - 10.1097/01.sla.0000143252.02142.3e [doi]
PST - ppublish
SO  - Ann Surg. 2004 Nov;240(5):757-73. doi: 10.1097/01.sla.0000143252.02142.3e.