PMID- 15494165
OWN - NLM
STAT- MEDLINE
DCOM- 20050207
LR  - 20131121
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1027
IP  - 1-2
DP  - 2004 Nov 19
TI  - GABAA-5-HT1A receptor interaction in the mediobasal hypothalamus.
PG  - 144-50
AB  - Both serotonin (5-HT) and gamma-aminobutyric acid (GABA) modulate female rat 
      lordosis behavior and appear to interact in their control of the behavior. The 
      current experiments were designed to investigate the interaction between these 
      two neurotransmitters in sexually receptive female rats. Ovariectomized female 
      rats, with bilateral cannulae directed toward the ventromedial nucleus of the 
      hypothalamus (VMN), were hormonally primed with 10 microg estradiol benzoate and 
      500 microg progesterone. Sexual behavior was examined after intracranial infusion 
      with 200 ng (+/-)-8-hydroxy 2-(di-n-propylamino)tetralin (8-OH-DPAT), 25 ng 
      (5-aminomethyl-3-hydroxyisoxazole)hydrobromide (muscimol), 10 ng bicuculline or a 
      combination of the drugs. As expected, 8-OH-DPAT reduced lordosis behavior and 
      muscimol attenuated this inhibition in a bicuculline-sensitive manner. Muscimol 
      alone also reduced lordosis behavior. These findings contrast with several 
      reports that muscimol facilitates lordosis behavior of suboptimally hormonally 
      primed female rats. The current outcome is discussed in terms of procedural 
      differences between the present experiment and earlier studies. It is suggested 
      that muscimol may enhance lordosis responding in suboptimally hormonally primed 
      rats by activation of GABAA receptors located dorsal to the VMN. In contrast, 
      activation of receptors located more ventrally within the mediobasal hypothalamus 
      (MBH) may inhibit the behavior of rats that are already sexually receptive.
FAU - Guptarak, J
AU  - Guptarak J
AD  - Department of Biology, Texas Woman's University, Denton, TX 76204, USA.
FAU - Selvamani, A
AU  - Selvamani A
FAU - Uphouse, L
AU  - Uphouse L
LA  - eng
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (GABA Agonists)
RN  - 0 (GABA Antagonists)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Serotonin Agents)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 1S4CJB5ZGN (estradiol 3-benzoate)
RN  - 2763-96-4 (Muscimol)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Bicuculline/pharmacology
MH  - Drug Interactions
MH  - Estradiol/*analogs & derivatives/pharmacology
MH  - Female
MH  - GABA Agonists/pharmacology
MH  - GABA Antagonists/pharmacology
MH  - Hypothalamus, Middle/drug effects/*metabolism
MH  - Muscimol/pharmacology
MH  - Ovariectomy/methods
MH  - Posture/*physiology
MH  - Progesterone/pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptor, Serotonin, 5-HT1A/*metabolism
MH  - Receptors, GABA-A/*metabolism
MH  - Serotonin Agents/pharmacology
MH  - Sexual Behavior, Animal/drug effects
MH  - Time Factors
EDAT- 2004/10/21 09:00
MHDA- 2005/02/08 09:00
CRDT- 2004/10/21 09:00
PHST- 2004/08/29 00:00 [accepted]
PHST- 2004/10/21 09:00 [pubmed]
PHST- 2005/02/08 09:00 [medline]
PHST- 2004/10/21 09:00 [entrez]
AID - S0006-8993(04)01444-1 [pii]
AID - 10.1016/j.brainres.2004.08.048 [doi]
PST - ppublish
SO  - Brain Res. 2004 Nov 19;1027(1-2):144-50. doi: 10.1016/j.brainres.2004.08.048.