PMID- 15496201
OWN - NLM
STAT- MEDLINE
DCOM- 20050329
LR  - 20220318
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 64
IP  - 5
DP  - 2004 Nov
TI  - Molecular analysis of HLA allele frequencies and haplotypes in Baloch of Iran 
      compared with related populations of Pakistan.
PG  - 581-7
AB  - The extreme polymorphism in different loci of the human leukocyte antigen (HLA) 
      system has been used as an invaluable tool for anthropological studies. 
      Determination of HLA allele and haplotype frequencies in different ethnic groups 
      is useful for population genetic analyses and the study of genetic relationships 
      among them. In the present study, molecular analysis of HLA-A, -B, -C, -DQA1, 
      -DQB1, and -DRB1 genes has been used to assign HLA allele and haplotype 
      frequencies in 100 unrelated healthy individuals from the Baloch ethnic group of 
      Iran. The results were compared with Baloch and other ethnic groups in the 
      neighboring Pakistan. The results of this study showed that the most frequent HLA 
      class I alleles were A*02011 (20.2%), B*4006 (11.1%), and C*04011 (28.6%). The 
      most common HLA class II alleles were DQA1*0101/2 (42.5%), DQB1*0201 (32%), and 
      DRB1*0301 (29%). Three-locus haplotype analysis revealed that 
      A*11011-B*4006-C*15021 (5.8%) and DQA1*0501-DQB1*0201-DRB1*0301 (22.1%) were the 
      most common HLA class I and II haplotypes, respectively, in this population. 
      Neighbor-joining tree based on DA genetic distances and correspondence analysis 
      according to HLA-A, -B, -DQB1, and -DRB1 allele frequencies showed that Baloch of 
      Iran are genetically very close to Baloch and Brahui of Pakistan. This may 
      reflect an admixture of Brahui and Baloch ethnic groups of Pakistan in the 
      Balochistan province of Iran.
FAU - Farjadian, S
AU  - Farjadian S
AD  - Immunology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Naruse, T
AU  - Naruse T
FAU - Kawata, H
AU  - Kawata H
FAU - Ghaderi, A
AU  - Ghaderi A
FAU - Bahram, S
AU  - Bahram S
FAU - Inoko, H
AU  - Inoko H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - *Gene Frequency
MH  - Genetic Markers
MH  - Genetics, Population
MH  - HLA Antigens/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Iran
MH  - Pakistan
MH  - Phylogeny
MH  - Polymorphism, Genetic
MH  - *Sequence Analysis, DNA
EDAT- 2004/10/22 09:00
MHDA- 2005/03/30 09:00
CRDT- 2004/10/22 09:00
PHST- 2004/10/22 09:00 [pubmed]
PHST- 2005/03/30 09:00 [medline]
PHST- 2004/10/22 09:00 [entrez]
AID - TAN302 [pii]
AID - 10.1111/j.1399-0039.2004.00302.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Nov;64(5):581-7. doi: 10.1111/j.1399-0039.2004.00302.x.