PMID- 15498141
OWN - NLM
STAT- MEDLINE
DCOM- 20050126
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 12
IP  - 5
DP  - 2004 Oct
TI  - [Progress of studies on VEC apoptosis-inducing proteins in snake venom and its 
      mechanism--review].
PG  - 708-12
AB  - Hemorrhagic snake venom specially induces apoptosis of VEC (vascular endothelial 
      cells). Five apoptosis-inducing proteins had been purified and characterized from 
      crude snake venom. Two of these are L-amino acid oxidase (LAO), the others belong 
      to metalloprotease/disintegrin family. LAO catalyzes H2O2 production by oxidizing 
      some plasma membrane proteins of VEC, disintegrins interfere with binding of 
      integrins with their ligands. The expression of p53 and bcl-2 increases during 
      VEC apoptosis induced by snake venom, moreover, the mRNA of bcl-2 is spliced into 
      two fragments. It has been proved that one of adhesion-dependent signal 
      molecules, alphavbeta3, and one of phospholipid signal molecules, PC-PLC 
      (phosphatidylcholine-specific phospholipase C), are involved in above 
      apoptosis-inducing signal transudation pathway. These results throw light on 
      finding out specific component from protein is snake venom. This component is 
      able to induce tumor vascular endothelial cells apoptosis. This review summarized 
      progress of research on hemorrhagic snake venoms.
FAU - Zhao, Qi-Tao
AU  - Zhao QT
AD  - Institute of Developmental Biology, School of Life Science, Shandong University, 
      Jinan 250100, China.
FAU - Xie, Kun
AU  - Xie K
FAU - Zhang, Jie
AU  - Zhang J
FAU - Miao, Jun-Ying
AU  - Miao JY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Snake Venoms)
RN  - EC 1.4.- (Amino Acid Oxidoreductases)
RN  - EC 1.4.3.2 (L-Amino Acid Oxidase)
SB  - IM
MH  - Amino Acid Oxidoreductases/pharmacology
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Endothelial Cells/cytology/*drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - L-Amino Acid Oxidase
MH  - Reactive Oxygen Species
MH  - Signal Transduction
MH  - Snake Venoms/chemistry/*pharmacology
RF  - 16
EDAT- 2004/10/23 09:00
MHDA- 2005/01/27 09:00
CRDT- 2004/10/23 09:00
PHST- 2004/10/23 09:00 [pubmed]
PHST- 2005/01/27 09:00 [medline]
PHST- 2004/10/23 09:00 [entrez]
AID - 1009-2137(2004)05-0708-05 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Oct;12(5):708-12.