PMID- 15498298
OWN - NLM
STAT- MEDLINE
DCOM- 20060922
LR  - 20061115
IS  - 0529-5815 (Print)
IS  - 0529-5815 (Linking)
VI  - 42
IP  - 18
DP  - 2004 Sep 22
TI  - [Comparative studies of the expression of estrogen receptor-alpha and estrogen 
      receptor-beta in prostatic carcinoma].
PG  - 1111-5
AB  - OBJECTIVE: To determine the expression of estrogen receptor-alpha (ERalpha) and 
      estrogen receptor-beta (ERbeta) in prostatic carcinoma (PCa). METHODS: The 
      expression of ERalpha and ERbeta was analysed in 32 cases of PCa, 12 cases of 
      normal prostate tissue and 32 cases of benign prostate hyperplasia (BPH) by 
      semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR), and 
      the genes were sequenced. RESULTS: Compared with the tissue of BPH, the ERalpha 
      expression significantly increased, but the ERbeta expression decreased in the 
      tissue of PCa (P < 0.01). Compared with in the early stage and high 
      differentiation of prostatic carcinoma, the ERalpha expression increased 
      obviously, but ERbeta expression decreased in the developed stage and low 
      differentiation (P < 0.01). ERalpha increased, but ERbeta decreased in 
      hormone-refractory prostatic carcinoma (P < 0.05). CONCLUSION: ERalpha and ERbeta 
      may play an important role in the development of PCa. It is shown that analysis 
      of the expression of ER, especially ERbeta in PCa, will benefit to the diagnosis 
      and treatment of this disease.
FAU - Yang, Guo-sheng
AU  - Yang GS
AD  - Department of Urology, First Affiliated Hospital, Medical College of Zhejiang 
      University, Hangzhou 310003, China. yang_guosheng@163.com
FAU - Chen, Zhao-dian
AU  - Chen ZD
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Wai Ke Za Zhi
JT  - Zhonghua wai ke za zhi [Chinese journal of surgery]
JID - 0153611
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Aged
MH  - Estrogen Receptor alpha/*biosynthesis
MH  - Estrogen Receptor beta/*biosynthesis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prostatic Hyperplasia/metabolism
MH  - Prostatic Neoplasms/*metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2004/10/23 09:00
MHDA- 2006/09/23 09:00
CRDT- 2004/10/23 09:00
PHST- 2004/10/23 09:00 [pubmed]
PHST- 2006/09/23 09:00 [medline]
PHST- 2004/10/23 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Wai Ke Za Zhi. 2004 Sep 22;42(18):1111-5.