PMID- 15498363
OWN - NLM
STAT- MEDLINE
DCOM- 20041130
LR  - 20111117
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 117
IP  - 10
DP  - 2004 Oct
TI  - Relationship between HLA-DQA1 polymorphism and genetic susceptibility to 
      idiopathic dilated cardiomyopathy.
PG  - 1449-52
AB  - BACKGROUND: Autoimmune mechanisms are likely to participate in the pathogenesis 
      of subgroup of idiopathic dilated cardiomyopathy (IDC), and components of the 
      major histocompatibility complex may serve as markers for the propensity to 
      develop immune-mediated myocardial damage. Human leukocyte antigen (HLA) class II 
      genes, especially highly polymorphic HLA-DQ genes, play an important role in the 
      activation of immune responses, and thus control the predisposition for or 
      protect from IDC. This study was conducted to investigate the HLA-DQA1 allele 
      polymorphisms in IDC patients and to explore the underlying immunological 
      mechanism and the hereditary susceptibility to IDC. METHODS: The polymerase chain 
      reaction sequence-specific primers (PCR-SSP) technique was used to analyze the 
      polymorphisms in the second exon of DQA1 in three groups: 72 IDC patients 
      diagnosed according to the criteria of World Health Organization (IDC group); 100 
      end-stage heart failure patients suffering from a disease of known etiology (HF 
      group); and 100 healthy subjects enrolled for the study during a routine health 
      survey (control group). Patients in the IDC group were stratified according to 
      ejection fraction (EF). Those with EF values were higher than 35% were placed 
      into subgroup 1; subgroup 2 included patients with an EF value of 15% - 35%; and 
      subgroup 3 consisted of those whose EF values less than 15%. RESULTS: The 
      frequency of HLA-DQA1 *0501 alleles was significantly higher in the IDC group 
      (0.39) than that in the HF group (0.12) and the control group (0.09) (both P < 
      0.05). Further analysis of the three IDC subgroups showed a higher frequency of 
      DQA1 *0501 among patients with lower EF values (both P < 0.05, compared with 
      subgroups 1 and 2). The frequency of DQA1 *0201 was higher in the control group 
      than that in the IDC group (P < 0.05). CONCLUSIONS: The HLA-DQA1 *0501 allele 
      confers susceptibility to IDC, while the DQA1 *0201 allele confers protection 
      against it, which indicates that genetic background involved in IDC and heart 
      failure is different. HLA-DQA1 genes are involved in the regulation of specific 
      immune responses by auto- or foreign anti-myocardium antibody.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Cardiology, First Affiliated Hospital, Harbin Medical University, 
      Harbin 150001, China. bear1999bear@sina.com
FAU - Li, Wei-min
AU  - Li WM
FAU - Sun, Ning-ling
AU  - Sun NL
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
EDAT- 2004/10/23 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/10/23 09:00
PHST- 2004/10/23 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/10/23 09:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 2004 Oct;117(10):1449-52.