PMID- 15499525
OWN - NLM
STAT- MEDLINE
DCOM- 20041228
LR  - 20211203
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 190
IP  - 10
DP  - 2004 Nov 15
TI  - Epidemiological and genetic correlates of incident Chlamydia trachomatis 
      infection in North American adolescents.
PG  - 1723-9
AB  - Epidemiological and genetic correlates of Chlamydia trachomatis infection were 
      examined prospectively in 124 male and 361 female adolescents at high risk for 
      human immunodeficiency virus type 1 (HIV-1) infection. Seventy percent of 
      subjects were African American, and 68% had HIV-1 infection. As expected, younger 
      age (<17 years), multiple sex partners (> or =2), and prior chlamydial infection 
      predicted chlamydial infection during a 6-56-month follow-up period (P=.02, 
      P=.02, and P=.03, respectively). Human leukocyte antigen (HLA) class II variant 
      DQB1*06 (mostly *0602 and *0603) was associated with chlamydial infection (49% 
      vs. 34%; adjusted relative odds [RO], 1.8; P=.005), as was HLA class I haplotype 
      B*44-Cw*04 (10% vs. 4%; RO, 3.2; P=.009). DQB1*06 was found in 9 (75%) of 12 
      female adolescents with chlamydial pelvic inflammatory disease. In contrast, sex, 
      ethnicity, and HIV-1 infection did not predict chlamydial infection. These 
      findings suggest that antigen presentation in adaptive immune responses may serve 
      as a major factor in effective control of C. trachomatis infection. The 
      underlying mechanisms remain to be experimentally elucidated.
FAU - Geisler, William M
AU  - Geisler WM
AD  - Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 
      35294-0022, USA.
FAU - Tang, Jianming
AU  - Tang J
FAU - Wang, Chengbin
AU  - Wang C
FAU - Wilson, Craig M
AU  - Wilson CM
FAU - Kaslow, Richard A
AU  - Kaslow RA
LA  - eng
GR  - HD-32830/HD/NICHD NIH HHS/United States
GR  - R30 CCR421113/CC/ODCDC CDC HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20041007
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Chlamydia Infections/*epidemiology/*genetics/immunology/microbiology
MH  - Chlamydia trachomatis/isolation & purification
MH  - Ethnicity
MH  - Female
MH  - Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - *Genetic Predisposition to Disease
MH  - HIV Infections/complications
MH  - HLA-B Antigens/analysis/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DQ Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Sexual Behavior
MH  - United States/epidemiology
EDAT- 2004/10/23 09:00
MHDA- 2004/12/29 09:00
CRDT- 2004/10/23 09:00
PHST- 2004/03/16 00:00 [received]
PHST- 2004/06/02 00:00 [accepted]
PHST- 2004/10/23 09:00 [pubmed]
PHST- 2004/12/29 09:00 [medline]
PHST- 2004/10/23 09:00 [entrez]
AID - JID32708 [pii]
AID - 10.1086/425077 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Nov 15;190(10):1723-9. doi: 10.1086/425077. Epub 2004 Oct 7.