PMID- 15501070
OWN - NLM
STAT- MEDLINE
DCOM- 20050322
LR  - 20091119
IS  - 0960-894X (Print)
IS  - 0960-894X (Linking)
VI  - 14
IP  - 23
DP  - 2004 Dec 6
TI  - Identification of peptidomimetic HTLV-I protease inhibitors containing 
      hydroxymethylcarbonyl (HMC) isostere as the transition-state mimic.
PG  - 5925-9
AB  - Towards the development of chemotherapy for the infection by human T-cell 
      leukemia virus type I (HTLV-I), we have established evaluation systems for HTLV-I 
      protease (PR) inhibitors using both recombinant and chemically synthesized HTLV-I 
      PRs. Newly synthesized substrate-based inhibitors containing 
      hydroxymethylcarbonyl (HMC) isostere showed potent anti-HTLV-I PR activity.
FAU - Maegawa, Hikoichiro
AU  - Maegawa H
AD  - Department of Medicinal Chemistry, Center for Frontier Research in Medicinal 
      Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
FAU - Kimura, Tooru
AU  - Kimura T
FAU - Arii, Yasuhiro
AU  - Arii Y
FAU - Matsui, Yasuko
AU  - Matsui Y
FAU - Kasai, Soko
AU  - Kasai S
FAU - Hayashi, Yoshio
AU  - Hayashi Y
FAU - Kiso, Yoshiaki
AU  - Kiso Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioorg Med Chem Lett
JT  - Bioorganic & medicinal chemistry letters
JID - 9107377
RN  - 0 (Protease Inhibitors)
RN  - EC 3.4.23.- (Aspartic Acid Endopeptidases)
RN  - EC 3.4.23.- (HTLV-1 protease)
SB  - IM
MH  - Amino Acid Sequence
MH  - Aspartic Acid Endopeptidases/*antagonists & inhibitors/genetics/metabolism
MH  - Humans
MH  - Molecular Sequence Data
MH  - Protease Inhibitors/*chemistry/pharmacology
EDAT- 2004/10/27 09:00
MHDA- 2005/03/23 09:00
CRDT- 2004/10/27 09:00
PHST- 2004/08/03 00:00 [received]
PHST- 2004/09/03 00:00 [accepted]
PHST- 2004/10/27 09:00 [pubmed]
PHST- 2005/03/23 09:00 [medline]
PHST- 2004/10/27 09:00 [entrez]
AID - S0960-894X(04)01146-1 [pii]
AID - 10.1016/j.bmcl.2004.09.034 [doi]
PST - ppublish
SO  - Bioorg Med Chem Lett. 2004 Dec 6;14(23):5925-9. doi: 10.1016/j.bmcl.2004.09.034.