PMID- 15501310
OWN - NLM
STAT- MEDLINE
DCOM- 20050419
LR  - 20131121
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 79
IP  - 2
DP  - 2004 Oct
TI  - Preexposure to MDMA ("Ecstasy") delays acquisition but facilitates MDMA-induced 
      reinstatement of amphetamine self-administration behavior in rats.
PG  - 331-42
AB  - The current experiment investigated the effect of 
      3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') preexposure on the 
      acquisition of intravenous amphetamine self-administration and the reinstatement 
      of amphetamine-seeking behavior by either MDMA or amphetamine. Rats were 
      preexposed to a 5-HT depleting regime of MDMA (5 mg/kg every hour for 4 h on two 
      consecutive days) or equivalent vehicle injections. Intravenous 
      self-administration of low dose d-amphetamine (0.03 mg/kg/infusion) on a FR1 
      schedule was subsequently assessed. The rats were then given 2 weeks of 
      extinction and tested for drug-seeking behavior with priming doses of amphetamine 
      or MDMA. Brains were analysed for monoamine content using high-performance liquid 
      chromatography (HPLC). MDMA-preexposed rats were initially slower to acquire 
      amphetamine self-administration. However, by day 6 of acquisition, there was no 
      difference from controls. Following extinction, amphetamine (1 mg/kg, i.p.) 
      reinstated drug seeking and produced locomotor hyperactivity in both MDMA- and 
      vehicle-pretreated animals. However, MDMA (5 mg/kg, i.p.) was only effective in 
      producing amphetamine seeking and hyperactivity in MDMA-pretreated rats. MDMA 
      pretreatment caused significant decreases in 5-hydroxy-indolacetic acid (5-HIAA) 
      and 5-HT in several brain regions. These results suggest that 5-HT depletion 
      induced by MDMA may initially slow the acquisition of amphetamine 
      self-administration but that MDMA preexposure may also sensitize animals to the 
      locomotor stimulating and priming effects of MDMA on drug-seeking behavior.
FAU - Morley, Kirsten C
AU  - Morley KC
AD  - School of Psychology, University of Sydney, NSW 2006, Australia.
FAU - Cornish, Jennifer L
AU  - Cornish JL
FAU - Li, Kong M
AU  - Li KM
FAU - McGregor, Iain S
AU  - McGregor IS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain/drug effects/metabolism
MH  - Dextroamphetamine/*administration & dosage
MH  - Drug Interactions
MH  - Extinction, Psychological/drug effects
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Self Administration
MH  - Serotonin/metabolism
MH  - Serotonin Agents/administration & dosage
MH  - Substance-Related Disorders/etiology
EDAT- 2004/10/27 09:00
MHDA- 2005/04/20 09:00
CRDT- 2004/10/27 09:00
PHST- 2004/01/23 00:00 [received]
PHST- 2004/08/06 00:00 [revised]
PHST- 2004/08/09 00:00 [accepted]
PHST- 2004/10/27 09:00 [pubmed]
PHST- 2005/04/20 09:00 [medline]
PHST- 2004/10/27 09:00 [entrez]
AID - S0091-3057(04)00253-9 [pii]
AID - 10.1016/j.pbb.2004.08.004 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2004 Oct;79(2):331-42. doi: 10.1016/j.pbb.2004.08.004.