PMID- 15501492
OWN - NLM
STAT- MEDLINE
DCOM- 20050419
LR  - 20061115
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 83
IP  - 1
DP  - 2004 Oct 30
TI  - Intraperitoneal leptin modifies macronutrient choice in self-selecting rats.
PG  - 65-72
AB  - This study aimed to evaluate the consequences on food intake and body weight (BW) 
      of leptin administration in rats receiving a choice between the three 
      macronutrients. Two studies were performed: during the first, rats received an 
      acute intraperitoneal (IP) leptin administration (1 mg/kg) twice (at 8 and 14 
      weeks of age), at the beginning of the nocturnal cycle, while during the second, 
      they received a chronic leptin infusion (osmotic minipump, 7 days). The total 
      24-h food intake after acute leptin injections was reduced by 14% and 17%, 
      respectively. Body weight gain (BWG) after leptin injections was about half that 
      seen on control days. Chronic leptin infusion reduced total intake, affecting 
      mainly protein (P). Fat intake increased slightly since day 2 and became 
      significant on the fourth day. After the leptin infusion, carbohydrate (CHO) 
      eaters (>35% carbohydrate/total energy) significantly reduced the carbohydrate 
      proportion in their total energy intake. There was no difference concerning 
      macronutrient selection by fat eaters (Hfat). Leptin infusion reduced the number 
      of mixed meals on the first day. In addition, the thermogenesis of brown adipose 
      tissue (BAT) was higher in leptin than in control (C) rats. Consequently, leptin 
      injections reduced food intake and BWG and increased thermogenesis, thus acting 
      on the two terms of the energy balance. Moreover, leptin has different effects on 
      macronutrient preferences, dependent upon age (tests 1 and 2) and the type (acute 
      or chronic) of injection. High leptinemia level related to age or to minipump 
      infusion lead to leptin resistance as found in old or obese subjects. It could 
      explain our results.
FAU - Wetzler, Sandrine
AU  - Wetzler S
AD  - UMR INRA/INAPG 914 Physiologie de la Nutrition et du Comportement Alimentaire 
      Institut National Agronomique de Paris-Grignon, 16, rue Claude Bernard. 75231 
      Paris Cedex 05, France.
FAU - Dumaz, Valerie
AU  - Dumaz V
FAU - Goubern, Marc
AU  - Goubern M
FAU - Tome, Daniel
AU  - Tome D
FAU - Larue-Achagiotis, Christiane
AU  - Larue-Achagiotis C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Drug Implants)
RN  - 0 (Hormones)
RN  - 0 (Leptin)
SB  - IM
MH  - Adipose Tissue, Brown/drug effects
MH  - Animals
MH  - Body Composition/drug effects
MH  - Diet
MH  - Dietary Carbohydrates
MH  - Drug Implants
MH  - Energy Metabolism/drug effects
MH  - Food Preferences/*drug effects
MH  - Hormones/blood
MH  - Injections, Intraperitoneal
MH  - Leptin/administration & dosage/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Weight Gain/drug effects
EDAT- 2004/10/27 09:00
MHDA- 2005/04/20 09:00
CRDT- 2004/10/27 09:00
PHST- 2004/02/17 00:00 [received]
PHST- 2004/06/18 00:00 [revised]
PHST- 2004/06/23 00:00 [accepted]
PHST- 2004/10/27 09:00 [pubmed]
PHST- 2005/04/20 09:00 [medline]
PHST- 2004/10/27 09:00 [entrez]
AID - S0031-9384(04)00311-7 [pii]
AID - 10.1016/j.physbeh.2004.06.024 [doi]
PST - ppublish
SO  - Physiol Behav. 2004 Oct 30;83(1):65-72. doi: 10.1016/j.physbeh.2004.06.024.