PMID- 15501543
OWN - NLM
STAT- MEDLINE
DCOM- 20050317
LR  - 20181130
IS  - 0223-5234 (Print)
IS  - 0223-5234 (Linking)
VI  - 39
IP  - 11
DP  - 2004 Nov
TI  - Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine 
      derivatives toward the human epidermoid carcinoma A431 cell line.
PG  - 939-46
AB  - Synthesis and biological evaluation of a new class of 
      1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives are reported. A 
      preliminary cellular assay system using the tumor cell line A431 responding to 
      epidermal growth factor (EGF) for its growth, shows that the new compounds are 
      potent inhibitors of cell growth. The inhibition of tumor cell proliferation is 
      not associated with blockage of EGF receptor (EGFR), but substantially due to the 
      interference with the signalling pathway at the level of Src tyrosine kinase and 
      at the level of the downstream effector signal mitogen activated protein kinases 
      (MAPKs), ERK1-2.
FAU - Schenone, Silvia
AU  - Schenone S
AD  - Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Genova, Viale 
      Benedetto XV, 16132 Genova, Italy. schensil@unige.it
FAU - Bruno, Olga
AU  - Bruno O
FAU - Bondavalli, Francesco
AU  - Bondavalli F
FAU - Ranise, Angelo
AU  - Ranise A
FAU - Mosti, Luisa
AU  - Mosti L
FAU - Menozzi, Giulia
AU  - Menozzi G
FAU - Fossa, Paola
AU  - Fossa P
FAU - Donnini, Sandra
AU  - Donnini S
FAU - Santoro, Annalisa
AU  - Santoro A
FAU - Ziche, Marina
AU  - Ziche M
FAU - Manetti, Fabrizio
AU  - Manetti F
FAU - Botta, Maurizio
AU  - Botta M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Med Chem
JT  - European journal of medicinal chemistry
JID - 0420510
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Pyrazoles)
RN  - 0 (Pyrimidines)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.2 (src-Family Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Antineoplastic Agents/*chemical synthesis/pharmacology
MH  - Carcinoma, Squamous Cell/*drug therapy
MH  - Cell Proliferation/*drug effects
MH  - Epidermal Growth Factor/pharmacology
MH  - ErbB Receptors/antagonists & inhibitors
MH  - Humans
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Pyrazoles/chemical synthesis/pharmacology
MH  - Pyrimidines/*chemical synthesis/pharmacology
MH  - Signal Transduction/drug effects
MH  - Tumor Cells, Cultured
MH  - src-Family Kinases/metabolism
EDAT- 2004/10/27 09:00
MHDA- 2005/03/18 09:00
CRDT- 2004/10/27 09:00
PHST- 2004/03/10 00:00 [received]
PHST- 2004/06/01 00:00 [revised]
PHST- 2004/07/21 00:00 [accepted]
PHST- 2004/10/27 09:00 [pubmed]
PHST- 2005/03/18 09:00 [medline]
PHST- 2004/10/27 09:00 [entrez]
AID - S0223-5234(04)00174-6 [pii]
AID - 10.1016/j.ejmech.2004.07.010 [doi]
PST - ppublish
SO  - Eur J Med Chem. 2004 Nov;39(11):939-46. doi: 10.1016/j.ejmech.2004.07.010.