PMID- 15501586
OWN - NLM
STAT- MEDLINE
DCOM- 20050113
LR  - 20131121
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 129
IP  - 2
DP  - 2004
TI  - N-methyl-D-aspartate receptor-independent long-term depression and depotentiation 
      in the sensorimotor cortex of the freely moving rat.
PG  - 273-81
AB  - Bidirectional modifications in synaptic efficacy are central components in recent 
      models of cortical learning and memory, and we previously demonstrated both 
      long-term synaptic potentiation (LTP) and long-term synaptic depression (LTD) in 
      the neocortex of the unanaesthetized adult rat. Here, we have examined the 
      effects of N-methyl-D-aspartate receptor (NMDAR) blockade on the induction of 
      LTD, LTP, and depotentiation of field potentials evoked in sensorimotor cortex by 
      stimulation of the white matter in the adult, freely moving rat. High frequency 
      (300 Hz) stimulation (HFS) was used to induce LTP and prolonged, low-frequency (1 
      Hz) stimulation was used to induce either depotentiation or LTD. LTD was 
      expressed as a reduction in the amplitude of the short and long-latency field 
      potential components, while depotentiation was expressed as a decrease in the 
      amplitude of a previously enhanced late component. Under NMDAR blockade, HFS 
      failed to induce LTP and instead produced a depression effect similar to LTD. 
      Following washout of the drug, HFS induced a normal LTP effect. Unlike LTP, LTD 
      and depotentiation were found to be NMDAR-independent in the neocortex of the 
      freely moving rat.
FAU - Froc, D J
AU  - Froc DJ
AD  - Department of Psychology, McMaster University, Hamilton, Ontario L8S 4K1, Canada. 
      david.froc@kwantlen.ca
FAU - Racine, R J
AU  - Racine RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Animals
MH  - Dizocilpine Maleate/pharmacology
MH  - Electrodes, Implanted
MH  - Evoked Potentials, Somatosensory/drug effects
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Male
MH  - Motor Cortex/drug effects/*physiology
MH  - Neuronal Plasticity/*drug effects
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*physiology
MH  - Somatosensory Cortex/drug effects/*physiology
EDAT- 2004/10/27 09:00
MHDA- 2005/01/14 09:00
CRDT- 2004/10/27 09:00
PHST- 2004/06/26 00:00 [accepted]
PHST- 2004/10/27 09:00 [pubmed]
PHST- 2005/01/14 09:00 [medline]
PHST- 2004/10/27 09:00 [entrez]
AID - S0306-4522(04)00548-2 [pii]
AID - 10.1016/j.neuroscience.2004.06.069 [doi]
PST - ppublish
SO  - Neuroscience. 2004;129(2):273-81. doi: 10.1016/j.neuroscience.2004.06.069.