PMID- 15506942
OWN - NLM
STAT- MEDLINE
DCOM- 20050418
LR  - 20041027
IS  - 0300-5127 (Print)
IS  - 0300-5127 (Linking)
VI  - 32
IP  - Pt 6
DP  - 2004 Dec
TI  - Vitamin A regulates proliferation and apoptosis of human T- and B-cells.
PG  - 982-4
AB  - Vitamin A is known to protect against infections, but it is not established how 
      vitamin A metabolites stimulate the immune system. We have investigated the 
      effects of physiological levels of retinoic acid on the function of normal human 
      T- and B-cells. Surprisingly, we found that the proliferation of B-cells was 
      inhibited by retinoids, and that this was due to rapid inhibition of the cell 
      cycle machinery regulating G(1)-to-S transition. In contrast, the proliferation 
      of T-cells was enhanced by physiological levels of retinoic acid, and the effect 
      was due to induction of IL-2 (interleukin 2). The 'non-death-receptor'-mediated 
      apoptosis of normal T-cells induced by prolonged (but single) stimulation of the 
      cells was also prevented by retinoid acid, and also this effect was mediated via 
      enhanced production of IL-2. The induction of IL-2 was at the transcriptional 
      level, and all the effects of vitamin A on both B-and T-cells were mediated via 
      the nuclear retinoic acid receptors (RARs), and not retinoid X receptors (RXRs).
FAU - Blomhoff, H K
AU  - Blomhoff HK
AD  - Department of Biochemistry, Institute of Basic Medical Sciences, University of 
      Oslo, P.O. Box 1112, Blindern, N-0317 Oslo, Norway. h.k.blomhoff@basalmed.uio.no
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Interleukin-2)
RN  - 11103-57-4 (Vitamin A)
SB  - IM
MH  - Apoptosis/*drug effects
MH  - B-Lymphocytes/*cytology/drug effects/physiology
MH  - Cell Division/*drug effects
MH  - Humans
MH  - Interleukin-2/biosynthesis
MH  - Lymphocyte Activation/drug effects
MH  - T-Lymphocytes/*cytology/drug effects/physiology
MH  - Vitamin A/*pharmacology
EDAT- 2004/10/28 09:00
MHDA- 2005/04/19 09:00
CRDT- 2004/10/28 09:00
PHST- 2004/10/28 09:00 [pubmed]
PHST- 2005/04/19 09:00 [medline]
PHST- 2004/10/28 09:00 [entrez]
AID - BST0320982 [pii]
AID - 10.1042/BST0320982 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2004 Dec;32(Pt 6):982-4. doi: 10.1042/BST0320982.