PMID- 15507335
OWN - NLM
STAT- MEDLINE
DCOM- 20050222
LR  - 20061115
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 95
IP  - 2-3
DP  - 2004 Dec
TI  - Cissampelos sympodialis Eichl. (Menispermaceae): oral treatment decreases IgE 
      levels and induces a Th1-skewed cytokine production in ovalbumin-sensitized mice.
PG  - 191-7
AB  - The murine model of ovalbumin (OVA)-induced allergy was used to evaluate the 
      effectiveness of oral treatment with the leaf extract of Cissampelos sympodialis 
      Eichl. (Menispermaceae) (CS) in the modulation of immunoglobulin E (IgE) 
      production and T cell activation. CS treatment with doses ranging from 200 to 600 
      mg/Kg/day for 15 days before and during OVA-sensitization promoted reduction in 
      total and OVA-specific serum IgE. CS at 400 or 600 mg/Kg/day also reduced paw 
      edema induced by local OVA challenge. Daily intake of up to 600 mg/Kg of oral CS 
      by BALB/c mice did not reduce weight gain, which is indicative of a lack of 
      systemic toxicity. To assess the effect of CS treatment on T cell proliferative 
      response to stimuli in vitro, the mitogenic response of spleen cells of treated 
      and control animals were evaluated. Cells from CS-treated animals showed an 
      elevated background proliferative response to concanavalin-A (Con-A) when 
      compared to those from control animals. Oral intake of CS increased the in vitro 
      production of IFN-gamma and IL-10 by Con-A stimulated cells. Mice treated with 
      200 mg/Kg/day CS showed increasing levels of IFN-gamma. These results show that 
      oral treatment with Cissampelos sympodialis extract has an immunomodulatory 
      effect, reducing allergy-associated responses possibly by a preferential 
      activation of Th1-type cytokines.
FAU - Bezerra-Santos, C R
AU  - Bezerra-Santos CR
AD  - Laboratorio de Tecnologia Farmaceutica, Departamento de Fisiologia e Patologia, 
      Universidade Federal da Paraiba, UFPB, Caixa Postal 5009, CEP 58, 051-970 Joao 
      Pessoa, Paraiba, Brazil.
FAU - Balestieri, F M P
AU  - Balestieri FM
FAU - Rossi-Bergmann, B
AU  - Rossi-Bergmann B
FAU - Pecanha, L M T
AU  - Pecanha LM
FAU - Piuvezam, M R
AU  - Piuvezam MR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - *Cissampelos
MH  - Cytokines/*biosynthesis
MH  - Edema/blood/chemically induced/drug therapy
MH  - Female
MH  - Immunoglobulin E/biosynthesis/*blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology/*toxicity
MH  - Plant Extracts/administration & dosage/isolation & purification
MH  - Plant Leaves
MH  - Rats
MH  - Rats, Wistar
MH  - Th1 Cells/*drug effects/metabolism
EDAT- 2004/10/28 09:00
MHDA- 2005/02/23 09:00
CRDT- 2004/10/28 09:00
PHST- 2003/10/23 00:00 [received]
PHST- 2004/06/30 00:00 [revised]
PHST- 2004/06/30 00:00 [accepted]
PHST- 2004/10/28 09:00 [pubmed]
PHST- 2005/02/23 09:00 [medline]
PHST- 2004/10/28 09:00 [entrez]
AID - S0378-8741(04)00390-3 [pii]
AID - 10.1016/j.jep.2004.06.037 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2004 Dec;95(2-3):191-7. doi: 10.1016/j.jep.2004.06.037.