PMID- 15508176
OWN - NLM
STAT- MEDLINE
DCOM- 20050421
LR  - 20070322
IS  - 1613-4125 (Print)
IS  - 1613-4125 (Linking)
VI  - 48
IP  - 6
DP  - 2004 Nov
TI  - Allergy assessment of foods or ingredients derived from biotechnology, 
      gene-modified organisms, or novel foods.
PG  - 413-23
AB  - The introduction of novel proteins into foods carries a risk of eliciting 
      allergic reactions in individuals sensitive to the introduced protein and a risk 
      of sensitizing susceptible individuals. No single predictive test exists to 
      perform a hazard assessment in relation to allergenic properties of newly 
      expressed proteins in gene-modified organisms (GMOs). Instead, performance of a 
      weighted risk analysis based on the decision tree approach has been suggested. 
      The individual steps of this analysis comprise sequence homology to known 
      allergens, specific or targeted serum screens for immunoglobulin E (IgE) 
      cross-reactions to known allergens, digestability studies of the proteins in 
      simulated gastric and/or intestinal fluids, and animal studies. These steps are 
      discussed and five examples of risk evaluation of GMOs or novel foods are 
      presented. These include ice-structuring protein derived from fish, microbial 
      transglutaminase, GMO-soybeans, amylase and the Nangai nut.
FAU - Poulsen, Lars K
AU  - Poulsen LK
AD  - Laboratory of Medical Allergology, Allergy Clinic, National University Hospital, 
      Copenhagen, Denmark. lkpallgy@inet.uni2.dk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Allergens)
RN  - 0 (Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*adverse effects/chemistry/genetics/isolation & purification
MH  - Animals
MH  - Biotechnology
MH  - Decision Trees
MH  - *Food Hypersensitivity/prevention & control
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Models, Animal
MH  - Organisms, Genetically Modified
MH  - Proteins/*adverse effects/chemistry/genetics
MH  - Safety
MH  - Sequence Homology, Amino Acid
RF  - 75
EDAT- 2004/10/28 09:00
MHDA- 2005/04/22 09:00
CRDT- 2004/10/28 09:00
PHST- 2004/10/28 09:00 [pubmed]
PHST- 2005/04/22 09:00 [medline]
PHST- 2004/10/28 09:00 [entrez]
AID - 10.1002/mnfr.200400029 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2004 Nov;48(6):413-23. doi: 10.1002/mnfr.200400029.