PMID- 15508179
OWN - NLM
STAT- MEDLINE
DCOM- 20050421
LR  - 20151119
IS  - 1613-4125 (Print)
IS  - 1613-4125 (Linking)
VI  - 48
IP  - 6
DP  - 2004 Nov
TI  - Food allergy to apple and specific immunotherapy with birch pollen.
PG  - 441-8
AB  - Conflicting results concerning the effect of specific pollen immunotherapy (SIT) 
      on allergy to plant foods have been reported. The aim of this study was to 
      investigate the effect of SIT using a birch pollen extract on food allergy with 
      focus on allergy to apple. Seventy-four birch pollen-allergic patients were 
      included in a double-blind, double-dummy, and placebo-controlled comparison of 
      sublingual-swallow (SLIT) and subcutaneous (SCIT) administration of a birch 
      pollen extract. Sixty-nine percent of these patients reported allergy to apple. 
      The clinical reactivity to apple was evaluated by open oral challenges with fresh 
      apple and a questionnaire. The immunoglobulin E (IgE)-reactivity was assessed by 
      skin prick test (SPT), specific IgE, and leukocyte histamine release (HR). Forty 
      patients were included in the final evaluation of the effect of SIT. The 
      challenges were positive in 9 (SCIT), 6 (SLIT), and 8 (placebo) patients after 
      treatment compared to 10, 4, and 10 patients, respectively, before SIT. The 
      symptom scores to apple during challenges decreased in all groups, but only 
      significantly in the placebo group (p = 0.03). As evaluated by the questionnaire, 
      the severity of food allergy in general did not change and there were no 
      differences between the groups. In spite of a significant effect on seasonal hay 
      fever symptoms and use of medication and decrease in IgE-reactivity, SIT was not 
      accompanied by a significant decrease in the severity of allergy to apple 
      compared to placebo. Therefore, oral allergy syndrome (OAS) to apple should not 
      be considered as a main criterion for selecting patients for birch pollen 
      immunotherapy at present.
FAU - Hansen, Kirsten Skamstrup
AU  - Hansen KS
AD  - Allergy Clinic 4222, National University Hospital, Copenhagen, Denmark. 
      ksh@dadlnet.dk
FAU - Khinchi, Marianne Sondergaard
AU  - Khinchi MS
FAU - Skov, Per Stahl
AU  - Skov PS
FAU - Bindslev-Jensen, Carsten
AU  - Bindslev-Jensen C
FAU - Poulsen, Lars K
AU  - Poulsen LK
FAU - Malling, Hans-Jorgen
AU  - Malling HJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Betula
MH  - Desensitization, Immunologic
MH  - Double-Blind Method
MH  - Female
MH  - Food Hypersensitivity/etiology/*therapy
MH  - Humans
MH  - Immunoglobulin E/biosynthesis/immunology
MH  - *Immunotherapy
MH  - Male
MH  - Malus/*adverse effects/immunology
MH  - Middle Aged
MH  - Pollen/*immunology
MH  - Skin Tests
MH  - Surveys and Questionnaires
EDAT- 2004/10/28 09:00
MHDA- 2005/04/22 09:00
CRDT- 2004/10/28 09:00
PHST- 2004/10/28 09:00 [pubmed]
PHST- 2005/04/22 09:00 [medline]
PHST- 2004/10/28 09:00 [entrez]
AID - 10.1002/mnfr.200400037 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2004 Nov;48(6):441-8. doi: 10.1002/mnfr.200400037.