PMID- 15510630
OWN - NLM
STAT- MEDLINE
DCOM- 20060307
LR  - 20211203
VI  - 16
IP  - 2
DP  - 2002 Feb
TI  - [Study on the expression of proto-oncogene eIF4E in laryngeal squamous 
      carcinoma].
PG  - 62-4
AB  - OBJECTIVE: To investigate the expression of the proto-oncogene eIF4E in laryngeal 
      squamous cell carcinoma and its relationship with clinical pathology. METHOD: 
      Sections of 37 samples of laryngeal squamous cell carcinoma (LSCC) and 10 samples 
      of vocal cords polyp were analyzed with anti-eIF4E polyclonal antibody utilizing 
      SP (Streptavidin Peroxidase) immunohistochemical technique. RESULT: All 37 LSCC 
      samples overexpressed eIF4E in the tumors (eIF4E score: 30 approximately 210), 
      whereas no staining was observed in 10 samples of vocal cords polyp (eIF4E score: 
      0). There was a significant correlation between overexpression of protein eIF4E 
      with T stage, N stage, histological grade, recurrence and the states of 
      metastases (P < 0.01). It did not correlate with age, sex, and site of tumor (P > 
      0.05). CONCLUSION: The eIF4E plays an important role on tumorgenesis, 
      development, invasion and metastases of laryngeal squamous cell carcinoma. There 
      was a correlation between the overexpression of protein eIF4E with TNM stage, 
      histological grade, recurrence and metastases. eIF4E in the laryngeal squamous 
      cell carcinoma can be considered as an independent prognostic factor and tumour 
      molecular marker.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otolaryngology-Head and Neck Surgery, Renji Hospital, Shanghai 
      Second Medical University, Shanghai 200001.
FAU - Zhou, Liang
AU  - Zhou L
FAU - Zheng, Luying
AU  - Zheng L
FAU - Gao, Yuping
AU  - Gao Y
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Eukaryotic Initiation Factor-4E)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Eukaryotic Initiation Factor-4E/*biosynthesis
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Prognosis
MH  - Proto-Oncogene Mas
EDAT- 2004/10/30 09:00
MHDA- 2006/03/08 09:00
CRDT- 2004/10/30 09:00
PHST- 2004/10/30 09:00 [pubmed]
PHST- 2006/03/08 09:00 [medline]
PHST- 2004/10/30 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 Feb;16(2):62-4.