PMID- 15511536
OWN - NLM
STAT- MEDLINE
DCOM- 20050315
LR  - 20200409
IS  - 0021-9975 (Print)
IS  - 1532-3129 (Electronic)
IS  - 0021-9975 (Linking)
VI  - 131
IP  - 4
DP  - 2004 Nov
TI  - Encephalomalacic lesions in pigs dually infected with porcine reproductive and 
      respiratory syndrome virus and pseudorabies virus.
PG  - 277-84
AB  - Four pigs (group 1) were infected with an aerosol containing porcine reproductive 
      and respiratory syndrome virus (PRRSV) followed 7 days later by pseudorabies 
      virus (PRV). Three further pigs (group 2) received PRRSV alone, two (group 3) 
      received PRV alone, and two (group 4) remained as uninfected controls. Despite 
      the admittedly small numbers of animals, the experiment appeared to throw light 
      on aspects of synergy. Thus, the group 1 pigs showed severe neurological signs 
      characterized by ataxia and muscular tremors. Total cell numbers in the 
      bronchoalveolar lavage fluid were increased in all PRRSV-infected pigs, and PRRSV 
      antigen was detected in the alveolar macrophages. Total cell numbers in the 
      cerebrospinal fluid of group 1 pigs were considerably greater than those 
      demonstrated in group 3, but no PRV antigen was found. Pigs of groups 1 and 2 
      showed pulmonary lesions, characterized by interstitial pneumonia and PRRSV 
      antigen immunolabelling. Non-suppurative encephalitis was found in five of the 
      six pigs of groups 1 and 3. In particular, one group 1 animal had severe 
      necrotizing encephalitis with intranuclear inclusion bodies and associated 
      immunolabelling of PRV antigen. The other three group 1 pigs had prominent 
      malacic lesions, with macrophages. These neuropathological findings strongly 
      suggested that PRRSV infection in pigs enhances the severity of brain lesions 
      caused PRV.
FAU - Narita, M
AU  - Narita M
AD  - National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki 305-0856, Japan.
FAU - Ishii, M
AU  - Ishii M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
SB  - IM
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid/cytology/virology
MH  - Cerebrospinal Fluid/cytology/virology
MH  - Encephalomalacia/pathology/*veterinary/virology
MH  - Herpesvirus 1, Suid/immunology/*isolation & purification
MH  - Leukocyte Count/veterinary
MH  - Porcine Reproductive and Respiratory Syndrome/*pathology/transmission
MH  - Porcine respiratory and reproductive syndrome virus/immunology/*isolation & 
      purification
MH  - Pseudorabies/*pathology/transmission
MH  - Specific Pathogen-Free Organisms
MH  - Swine
PMC - PMC7127378
EDAT- 2004/10/30 09:00
MHDA- 2005/03/16 09:00
PMCR- 2004/08/11
CRDT- 2004/10/30 09:00
PHST- 2003/11/17 00:00 [received]
PHST- 2004/05/04 00:00 [accepted]
PHST- 2004/10/30 09:00 [pubmed]
PHST- 2005/03/16 09:00 [medline]
PHST- 2004/10/30 09:00 [entrez]
PHST- 2004/08/11 00:00 [pmc-release]
AID - S0021997504000660 [pii]
AID - S0021-9975(04)00066-0 [pii]
AID - 10.1016/j.jcpa.2004.05.001 [doi]
PST - ppublish
SO  - J Comp Pathol. 2004 Nov;131(4):277-84. doi: 10.1016/j.jcpa.2004.05.001.