PMID- 15513316
OWN - NLM
STAT- MEDLINE
DCOM- 20050317
LR  - 20071115
IS  - 1401-7431 (Print)
IS  - 1401-7431 (Linking)
VI  - 38
IP  - 5
DP  - 2004 Oct
TI  - Tumor necrosis factor gene polymorphisms and inflammatory response in coronary 
      artery bypass grafting patients.
PG  - 312-7
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha), a key factor in the 
      inflammatory cascade, has been implicated in coronary artery disease. Two 
      biallelic polymorphisms in the TNF gene locus (TNFA at position -308 and TNFB at 
      +252) may influence TNF-alpha production. Individuals with the rare TNFA2 allele 
      or TNFB2 homozygosity have augmented TNF-alpha production. We investigated the 
      genotypes associated with increased TNF-alpha production in coronary artery 
      bypass grafting (CABG) patients and if these genotypes influence the magnitude of 
      the postoperative inflammatory response. METHODS: TNF gene polymorphisms were 
      analyzed by multiplex fluorescent solid-phase minisequencing in 86 CABG patients. 
      Plasma concentrations of TNF-alpha, IL-6 and C3a and C-reactive protein (CRP) 
      were analyzed before and after surgery in 45 of the patients and compared with 
      genetically high and low TNF-alpha producers. RESULTS: Thirty percent of the 
      patients carried the TNFA2 allele and 45% were TNFB2 homozygous. The allelic 
      frequencies were TNFA1/TNFA2 = 0.84/0.16 and TNFB1/TNFB2 = 0.32/0.68. Pre- and 
      postoperative levels of TNF-alpha, IL-6, C3a and CRP did not differ significantly 
      between genetically high and low TNF-alpha producers. CONCLUSIONS: The frequency 
      of high TNF-alpha producing genotypes in a CABG population was comparable to that 
      previously reported from normal populations. Furthermore, we found no evidence 
      that the investigated TNF-alpha gene polymorphisms influence postoperative 
      inflammatory response after uncomplicated coronary surgery.
FAU - Westerberg, Martin
AU  - Westerberg M
AD  - Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 
      Gothenburg, Sweden. martin.westerberg@hjl.gu
FAU - Bengtsson, Anders
AU  - Bengtsson A
FAU - Ricksten, Anne
AU  - Ricksten A
FAU - Jeppsson, Anders
AU  - Jeppsson A
LA  - eng
PT  - Comparative Study
PT  - Corrected and Republished Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand Cardiovasc J
JT  - Scandinavian cardiovascular journal : SCJ
JID - 9708377
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CRF - Scand Cardiovasc J. 2004 Jun;38(3):172-7. PMID: 15223716
MH  - Aged
MH  - Alleles
MH  - *Coronary Artery Bypass
MH  - Coronary Artery Disease/*genetics/surgery
MH  - Female
MH  - Humans
MH  - Inflammation/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2004/10/30 09:00
MHDA- 2005/03/18 09:00
CRDT- 2004/10/30 09:00
PHST- 2004/10/30 09:00 [pubmed]
PHST- 2005/03/18 09:00 [medline]
PHST- 2004/10/30 09:00 [entrez]
AID - X3TTATA2VRDFEUVU [pii]
AID - 10.1080/14017430410031795 [doi]
PST - ppublish
SO  - Scand Cardiovasc J. 2004 Oct;38(5):312-7. doi: 10.1080/14017430410031795.