PMID- 15513357
OWN - NLM
STAT- MEDLINE
DCOM- 20041123
LR  - 20220409
IS  - 0036-5521 (Print)
IS  - 0036-5521 (Linking)
VI  - 39
IP  - 8
DP  - 2004 Aug
TI  - Atopic manifestations are more common in patients with Crohn disease than in the 
      general population.
PG  - 731-6
AB  - BACKGROUND: The role of TNF-alpha in Crohn disease is now well established and 
      anti-TNF-alpha is frequently used as a second- or third-line treatment. Tumor 
      necrosis factor-alpha (TNF-alpha) is traditionally associated with macrophages 
      but has recently also been found in mast cells of the ileal wall in patients with 
      Crohn disease. As it is well known that mast cells and TNF-alpha play important 
      roles in atopic manifestations like asthma, allergic rhinitis; and eczema the aim 
      of this study was to investigate whether these are seen more commonly in Crohn 
      patients than in the general population. METHODS: Patients with Crohn disease (n 
      = 308), aged 18-50 years, living in the Linkoping region in southeast Sweden, 
      were asked to answer a questionnaire regarding the presence of any kind of atopic 
      manifestations. The questionnaire was also sent to 930 controls collected from 
      the Southeastern Region Population Registry. The controls were matched according 
      to age, sex, and place of residence. RESULTS: The response rate among the Crohn 
      patients was 91% (280/308) and among controls 84% (779/930). Eczema was a 
      significantly more frequent manifestation, being almost twice as common in Crohn 
      patients (27%) as in the general population (16%). Adjustment by logistic 
      regression for place of residence, gender, age and coexistence of any other 
      atopic manifestation did not change the odds ratios significantly. CONCLUSION: 
      Atopic manifestations as a group, and eczema as a single manifestation, are 
      significantly more frequent in Crohn patients than in the general population.
FAU - Myrelid, P
AU  - Myrelid P
AD  - Dept. of Surgery, Unit of Colorectal Surgery, University Hospital, Linkoping, 
      Sweden. par.myrelid@lio.se
FAU - Dufmats, M
AU  - Dufmats M
FAU - Lilja, I
AU  - Lilja I
FAU - Grinn, C
AU  - Grinn C
FAU - Lannerstad, O
AU  - Lannerstad O
FAU - Sjodahl, R
AU  - Sjodahl R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asthma/complications
MH  - Crohn Disease/*complications/immunology
MH  - Eczema/complications
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*complications
MH  - Male
MH  - Middle Aged
MH  - Rhinitis, Allergic, Perennial/complications
MH  - Rhinitis, Allergic, Seasonal/complications
EDAT- 2004/10/30 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/10/30 09:00
PHST- 2004/10/30 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/10/30 09:00 [entrez]
AID - 3D7BE0CCJFKBW73W [pii]
AID - 10.1080/00365520410005955 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2004 Aug;39(8):731-6. doi: 10.1080/00365520410005955.