PMID- 15517479
OWN - NLM
STAT- MEDLINE
DCOM- 20050318
LR  - 20181113
IS  - 0364-2313 (Print)
IS  - 0364-2313 (Linking)
VI  - 28
IP  - 12
DP  - 2004 Dec
TI  - Prospective evaluation of imaging procedures for the detection of 
      pancreaticoduodenal endocrine tumors in patients with multiple endocrine 
      neoplasia type 1.
PG  - 1317-22
AB  - Early identification of pancreaticoduodenal endocrine tumors (PETs) in multiple 
      endocrine neoplasia type 1 (MEN-1) is mandatory, because these tumors represent 
      the most common cause of death within the syndrome. The diagnostic value of 
      imaging procedures has therefore been evaluated in a prospective observational 
      study. Between December 1997 and June 2003 twenty-two MEN-1 patients with 
      genetically confirmed disease were followed for PETs using a standardized 
      screening program with serum hormone measurements, endoscopic ultrasonography 
      (EUS), computed tomography (CT), and somatostatin-receptor scintigraphy (SRS). 
      Results could be validated by surgery and histopathology in 13 patients during 18 
      operations. In 12 asymptomatic patients with tumors measuring 10 mm or less, who 
      have not yet undergone operation, PETs were detected by EUS in 12/12, by CT in 
      1/12, and by SRS in 2/11 cases. In 13 patients who have undergone surgical 
      exploration EUS, CT, and SRS were true positive in 12 of 16, 7 of 13, and 12 of 
      17 cases, respectively, although the number of tumors detected by each imaging 
      procedure alone was lower than the number detected intraoperatively and 
      histopathologically in almost every case. A solitary liver metastasis in one 
      patient and a nonfunctioning PET recurrence in another were identified only by 
      SRS. Endoscopic ultrasonography is the most sensitive imaging procedure for the 
      detection of small (< or = 10 mm) PETs in MEN-1, whereas SRS is the procedure of 
      choice for the identification of metastases of MEN-1 PETs-i.e., for staging. 
      Detection of PETs at an early stage by an aggressive screening program using EUS 
      may lead to prompt surgical intervention and improved prognosis of MEN-1 PETs.
FAU - Langer, Peter
AU  - Langer P
AD  - Department of Surgery, Philipps-University Hospital, Baldingerstrasse, D-35043 
      Marburg, Germany. langerp@mailer.uni-marburg.de
FAU - Kann, Peter H
AU  - Kann PH
FAU - Fendrich, Volker
AU  - Fendrich V
FAU - Richter, Gerd
AU  - Richter G
FAU - Diehl, Saskia
AU  - Diehl S
FAU - Rothmund, Matthias
AU  - Rothmund M
FAU - Bartsch, Detlef K
AU  - Bartsch DK
LA  - eng
PT  - Journal Article
DEP - 20041111
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
RN  - 0 (Receptors, Somatostatin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Duodenal Neoplasms/*diagnosis/diagnostic imaging
MH  - Endosonography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis
MH  - Pancreatic Neoplasms/*diagnosis/diagnostic imaging
MH  - Prospective Studies
MH  - Receptors, Somatostatin
EDAT- 2004/11/02 09:00
MHDA- 2005/03/19 09:00
CRDT- 2004/11/02 09:00
PHST- 2004/11/02 09:00 [pubmed]
PHST- 2005/03/19 09:00 [medline]
PHST- 2004/11/02 09:00 [entrez]
AID - 10.1007/s00268-004-7642-7 [doi]
PST - ppublish
SO  - World J Surg. 2004 Dec;28(12):1317-22. doi: 10.1007/s00268-004-7642-7. Epub 2004 
      Nov 11.