PMID- 15518648
OWN - NLM
STAT- MEDLINE
DCOM- 20050125
LR  - 20061115
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1028
IP  - 1
DP  - 2004 Nov 26
TI  - Inactivation of the medial prefrontal cortex with the GABAA receptor agonist 
      muscimol increases open-arm activity in the elevated plus-maze and attenuates 
      shock-probe burying in rats.
PG  - 112-5
AB  - This study examined the effects of infusions of a direct GABA(A) receptor 
      agonist, muscimol, into the medial prefrontal cortex (MPFC), on fear behavior 
      measured in the elevated plus-maze and shock-probe burying tests. Bilateral 
      infusions of either a 0.175 or 4 nmol/0.5 microl dose of muscimol increased the 
      percentage of entries and time spent in the open arms, and attenuated shock-probe 
      burying. These findings indicate that intra-MPFC infusions of muscimol induce 
      anxiolysis, and suggest that the direct stimulation of MPFC GABA(A) receptors 
      attenuates fear-related behavior.
FAU - Shah, Akeel A
AU  - Shah AA
AD  - Department of Psychology, University of Alberta P217 Biological Sciences 
      Building, Edmonton, AB, Canada T6G 2E9. aashah@ualberta.ca
FAU - Sjovold, Travis
AU  - Sjovold T
FAU - Treit, Dallas
AU  - Treit D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (GABA Agonists)
RN  - 0 (Receptors, GABA-A)
RN  - 2763-96-4 (Muscimol)
SB  - IM
MH  - Animals
MH  - Anxiety/*chemically induced
MH  - Dose-Response Relationship, Drug
MH  - Exploratory Behavior/drug effects/*physiology
MH  - Fear/drug effects/*physiology
MH  - GABA Agonists/pharmacology
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Microinjections
MH  - Muscimol/pharmacology
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Punishment
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, GABA-A/drug effects/*physiology
EDAT- 2004/11/03 09:00
MHDA- 2005/01/26 09:00
CRDT- 2004/11/03 09:00
PHST- 2004/08/20 00:00 [accepted]
PHST- 2004/11/03 09:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2004/11/03 09:00 [entrez]
AID - S0006-8993(04)01351-4 [pii]
AID - 10.1016/j.brainres.2004.08.061 [doi]
PST - ppublish
SO  - Brain Res. 2004 Nov 26;1028(1):112-5. doi: 10.1016/j.brainres.2004.08.061.