PMID- 15521238
OWN - NLM
STAT- MEDLINE
DCOM- 20041130
LR  - 20111117
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 87
IP  - 7
DP  - 2004 Jul
TI  - No expression of human leukocyte antigen G (HLA-G) in colorectal cancer cells.
PG  - 816-8
AB  - Although there is a specific antitumor immune response in the body, colorectal 
      cancer cells progressively develop. This fact indicated that the cancer cells 
      could have a variety of mechanisms to evade or escape the immune system. HLA-G is 
      identified to inhibit the recognition of NK-cell in various kinds of cancers. 
      This study investigated the expression of HLA-G in colorectal cancer. Eighty five 
      specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were 
      examined by immunohistochemistry and RT-PCR for the detection of human leukocyte 
      antigen (HLA)-G The expression of HLA-G was not found in all colorectal specimens 
      (85/85) both protein level and transcription level, suggesting that the 
      expression of HLA-G is not a possible immune evasion mechanism of colorectal 
      cancer cell.
FAU - Leelawat, Kawin
AU  - Leelawat K
AD  - Department of Anatomy, Faculty of Science, Mahidol University, Thailand. 
      kawin@tubtim.cri.or.th
FAU - Engprasert, Surang
AU  - Engprasert S
FAU - Pongchai-rerk, Urai
AU  - Pongchai-rerk U
FAU - Tuchinda, Supatip
AU  - Tuchinda S
FAU - Suthipintawong, Cheepsumon
AU  - Suthipintawong C
FAU - Leardkamolkarn, Vijittra
AU  - Leardkamolkarn V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adenomatous Polyps/metabolism
MH  - Carcinoma in Situ/metabolism
MH  - Colorectal Neoplasms/*metabolism
MH  - HLA Antigens/*metabolism
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2004/11/04 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/11/04 09:00
PHST- 2004/11/04 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/11/04 09:00 [entrez]
PST - ppublish
SO  - J Med Assoc Thai. 2004 Jul;87(7):816-8.