PMID- 15521331
OWN - NLM
STAT- MEDLINE
DCOM- 20050202
LR  - 20190922
IS  - 0363-9045 (Print)
IS  - 0363-9045 (Linking)
VI  - 30
IP  - 8
DP  - 2004 Sep
TI  - Comparison of the TSI Model 3306 Impactor Inlet with the Andersen Cascade 
      Impactor: solution metered dose inhalers.
PG  - 859-68
AB  - The product performance of a series of solution Metered Dose Inhalers (MDIs) were 
      evaluated using the TSI Model 3306 Impactor Inlet and the Andersen Cascade 
      Impactor (ACI). The goal of the study was to test whether the fine particle and 
      coarse particle depositions obtained using the Model 3306 were comparable to 
      those results obtained by ACI testing. The analysis using the Model 3306 was 
      performed as supplied by the manufacturer as well as with 20 cm and 40 cm 
      vertical extensions that were inserted between the Model 3306 and the USP Inlet. 
      Nine different solution formulations were evaluated. The drug concentrations 
      ranged from 0.08 to 0.8% w/w and the ethanol cosolvent concentration varied 
      between 5 and 20% w/w. In general, it was found that good correlations between 
      the two instruments were obtained. However, for formulations containing 10-20% 
      w/w ethanol it is shown that an extension fitted to the Model 3306 yielded an 
      improved correlation to those obtained from the ACI.
FAU - Myrdal, Paul B
AU  - Myrdal PB
AD  - College of Pharmacy, University of Arizona, Tucson, Arizona, USA. 
      myrdal@pharmacy.arizona.edu
FAU - Stein, Stephen W
AU  - Stein SW
FAU - Mogalian, Erik
AU  - Mogalian E
FAU - Hoye, William
AU  - Hoye W
FAU - Gupta, Abhishek
AU  - Gupta A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Drug Dev Ind Pharm
JT  - Drug development and industrial pharmacy
JID - 7802620
RN  - 0 (Pharmaceutical Solutions)
RN  - KGZ1SLC28Z (Beclomethasone)
SB  - IM
MH  - Beclomethasone/chemistry/pharmacokinetics
MH  - Drug Delivery Systems/instrumentation/methods
MH  - Equipment Design/*methods/*standards
MH  - *Metered Dose Inhalers
MH  - Particle Size
MH  - Pharmaceutical Solutions/*chemistry
MH  - Technology, Pharmaceutical/methods
EDAT- 2004/11/04 09:00
MHDA- 2005/02/03 09:00
CRDT- 2004/11/04 09:00
PHST- 2004/11/04 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/11/04 09:00 [entrez]
AID - 10.1081/ddc-200034575 [doi]
PST - ppublish
SO  - Drug Dev Ind Pharm. 2004 Sep;30(8):859-68. doi: 10.1081/ddc-200034575.