PMID- 15522186
OWN - NLM
STAT- MEDLINE
DCOM- 20051209
LR  - 20151119
VI  - 23
IP  - 11
DP  - 2004 Nov
TI  - [Correlation of FHIT expression to cell proliferation and metastasis of laryngeal 
      squamous cell carcinoma].
PG  - 1338-41
AB  - BACKGROUND & OBJECTIVE: Fragile histidine triad (FHIT) gene, a candidate tumor 
      suppressor gene, located at 3pl4.2, spans the most common fragile site, FRA3B, in 
      human genomes. It is altered in many human cancers, such as head and neck 
      squamous cell carcinoma. This study was to investigate correlation of FHIT 
      expression to cell proliferation and metastasis of laryngeal squamous cell 
      carcinoma (LSCC). METHODS: Expression of FHIT protein, and proliferating cell 
      nuclear antigen (PCNA) was detected by SP immunohistochemistry in 41 specimens of 
      LSCC and their matched adjacent non-cancerous epithelium (NCE). RESULTS: Positive 
      rates of FHIT in NCE, and LSCC were 100.0% (41/41), and 46.3% (19/41) (P< 0.01); 
      in LSCC of stage I-II, and stage III-IV were 69.6% (16/23), and 16.7% (3/18) (P< 
      0.01); in lymph node metastasis group, and no metastasis group were 20.0% (3/15), 
      and 61.5% (16/26) (P< 0.05). PCNA labeling indexes in NCE, and LSCC were 
      (9.98+/-2.34)%, and (50.71+/-13.64)% (P< 0.01). In LSCC, expression of FHIT 
      negatively correlated with PCNA (P< 0.05). CONCLUSION: Low expression of FHIT 
      might play an important role in cell proliferation and metastasis of LSCC, FHIT 
      might be a useful marker for evaluating biological behaviors of LSCC.
FAU - Yin, De-Tao
AU  - Yin DT
AD  - Department of General Surgery, The First Affiliated Hospital, Zhengzhou 
      University, Zhengzhou, Henan 450 052, P.R. China. detaoyin@zzu.edu.cn
FAU - Lu, Xiu-Bo
AU  - Lu XB
FAU - Dong, Ming-Min
AU  - Dong MM
FAU - Qiu, Xin-Guang
AU  - Qiu XG
FAU - Wang, Qing-Zhao
AU  - Wang QZ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Ai Zheng
JT  - Ai zheng = Aizheng = Chinese journal of cancer
JID - 9424852
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - 0 (fragile histidine triad protein)
RN  - EC 3.6.- (Acid Anhydride Hydrolases)
SB  - IM
MH  - Acid Anhydride Hydrolases/*metabolism
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor
MH  - Carcinoma, Squamous Cell/*metabolism/secondary
MH  - *Cell Proliferation
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*metabolism
MH  - Neoplasm Staging
MH  - Proliferating Cell Nuclear Antigen/metabolism
EDAT- 2004/11/04 09:00
MHDA- 2005/12/13 09:00
CRDT- 2004/11/04 09:00
PHST- 2004/11/04 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2004/11/04 09:00 [entrez]
AID - 1000467X2004111338 [pii]
PST - ppublish
SO  - Ai Zheng. 2004 Nov;23(11):1338-41.