PMID- 15522929
OWN - NLM
STAT- MEDLINE
DCOM- 20050210
LR  - 20050111
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 90
IP  - 1
DP  - 2005 Jan
TI  - Gonadotroph tumor associated with multiple endocrine neoplasia type 1.
PG  - 570-4
AB  - Although anterior pituitary tumors constitute a main clinical feature of multiple 
      endocrine neoplasia type 1 (MEN1), and most types of pituitary tumors have been 
      associated with MEN1, gonadotroph tumors have not previously been recognized 
      clinically as part of this syndrome. We report here a woman who presented with 
      ovarian hyperstimulation due to a gonadotroph tumor that was confirmed 
      biochemically and immunohistochemically. She then developed hyperparathyroidism, 
      and she was found to have three hypercellular parathyroid glands. Subsequently, 
      she developed a temporal lobe metastasis of the gonadotroph tumor, demonstrating 
      that it was a gonadotroph carcinoma. The diagnosis of MEN1 was confirmed by 
      finding a deletion mutation (c.307delC) on the second exon of the MEN1 gene that 
      predicts truncation of the resulting menin protein 15 codons downstream from the 
      deletion (p.Leu103fsX15). This case illustrates that gonadotroph tumors, like 
      other pituitary tumors, can be part of MEN1. The clinical implications of this 
      case are that the clinical and biochemical features of gonadotroph tumors should 
      be considered when evaluating patients for MEN1, and MEN1 should be considered in 
      patients who have gonadotroph tumors.
FAU - Benito, Maria
AU  - Benito M
AD  - Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 
      19104-6149, USA.
FAU - Asa, Sylvia L
AU  - Asa SL
FAU - Livolsi, Virginia A
AU  - Livolsi VA
FAU - West, Valerie A
AU  - West VA
FAU - Snyder, Peter J
AU  - Snyder PJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20041102
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism/etiology
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Parathyroid Glands/pathology
MH  - Pituitary Neoplasms/*etiology/pathology
MH  - Proto-Oncogene Proteins/genetics
MH  - Temporal Lobe/pathology
EDAT- 2004/11/04 09:00
MHDA- 2005/02/11 09:00
CRDT- 2004/11/04 09:00
PHST- 2004/11/04 09:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/11/04 09:00 [entrez]
AID - jc.2004-1373 [pii]
AID - 10.1210/jc.2004-1373 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2005 Jan;90(1):570-4. doi: 10.1210/jc.2004-1373. Epub 
      2004 Nov 2.