PMID- 15523160
OWN - NLM
STAT- MEDLINE
DCOM- 20050203
LR  - 20220318
IS  - 1234-1983 (Print)
IS  - 1234-1983 (Linking)
VI  - 45
IP  - 4
DP  - 2004
TI  - Correlation of HLA-Cw*06 allele frequency with some clinical features of 
      psoriasis vulgaris in the population of northern Poland.
PG  - 473-6
AB  - Psoriasis is a common skin disease with a genetic background and significant 
      human leukocyte antigen (HLA) associations. HLA-Cw6 is the most frequently 
      described association, particularly with psoriasis of the early onset type. Few 
      studies of its correlation with various psoriasis clinical phenotypes and 
      severity of the disease have been published so far; none in the Polish 
      population. In this study 78 patients with psoriasis vulgaris were evaluated 
      clinically and subdivided according to the age of onset and the type of 
      psoriasis. A system of disease severity evaluation was applied to each patient. 
      All patients and the control group (70 unrelated persons) were typed for 
      HLA-Cw*06. The results show that Cw*06 allele frequency was higher in psoriatics 
      than in the control group. Our investigation confirms that the Cw*06 allele is 
      positively associated with psoriasis vulgaris of the early onset type, with a 
      positive family history and its more severe form.
FAU - Szczerkowska-Dobosz, Aneta
AU  - Szczerkowska-Dobosz A
AD  - Department of Dermatology, Venerology and Allergology, Medical University, 
      Debinki 7, 80-211 Gdansk, Poland. aneta_dobosz@wp.pl
FAU - Rebala, Krzysztof
AU  - Rebala K
FAU - Szczerkowska, Zofia
AU  - Szczerkowska Z
FAU - Witkowska-Tobola, Anna
AU  - Witkowska-Tobola A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Appl Genet
JT  - Journal of applied genetics
JID - 9514582
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*06 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Female
MH  - *Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - *Genetics, Population
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Poland/epidemiology
MH  - Psoriasis/classification/epidemiology/*genetics
MH  - Severity of Illness Index
EDAT- 2004/11/04 09:00
MHDA- 2005/02/04 09:00
CRDT- 2004/11/04 09:00
PHST- 2004/11/04 09:00 [pubmed]
PHST- 2005/02/04 09:00 [medline]
PHST- 2004/11/04 09:00 [entrez]
AID - 238 [pii]
PST - ppublish
SO  - J Appl Genet. 2004;45(4):473-6.