PMID- 15526252
OWN - NLM
STAT- MEDLINE
DCOM- 20050303
LR  - 20220321
IS  - 0010-440X (Print)
IS  - 0010-440X (Linking)
VI  - 45
IP  - 6
DP  - 2004 Nov-Dec
TI  - Psychosocial impairment and recurrence of major depression.
PG  - 423-30
AB  - Major depressive disorder is often marked by multiple recurrences. Unfortunately, 
      it is difficult to predict specifically which patients will suffer a recurrence. 
      This study examined whether psychosocial impairment is a risk factor for 
      recurrence. A total of 290 subjects with unipolar major depressive disorder 
      according to Research Diagnostic Criteria (RDC) were prospectively followed for 
      up to 15 years as part of the Collaborative Depression Study (CDS), a multicenter 
      longitudinal observational study of the mood disorders. Follow-up data on course 
      of illness and psychosocial functioning were collected with the Longitudinal 
      Interval Follow-up Evaluation (LIFE). The association of psychosocial impairment 
      with recurrence of major depression was examined with mixed-effects logistic 
      regression. The mean (SD) score for psychosocial functioning during recovery from 
      an episode of major depression was 9.0 (2.7), with a possible range of 4 (no 
      impairment) to 20 (severe impairment). For euthymic subjects who recovered from 
      an episode of major depression, elevated psychosocial impairment was 
      significantly associated with subsequent recurrence of major depression, with an 
      odds ratio of 1.12 (95% confidence interval [CI], 1.06 to 1.19). The odds ratio 
      of 1.12 indicates that for each 1-point increase in the functional impairment 
      score, the risk of recurrence increases by about 12%. In patients who have 
      recovered from an episode of major depression, the presence of psychosocial 
      impairment may help identify who is at increased risk of recurrence.
FAU - Solomon, David A
AU  - Solomon DA
AD  - Department of Psychiatry and Human Behavior, Brown University, Providence, RI, 
      USA.
FAU - Leon, Andrew C
AU  - Leon AC
FAU - Endicott, Jean
AU  - Endicott J
FAU - Mueller, Timothy I
AU  - Mueller TI
FAU - Coryell, William
AU  - Coryell W
FAU - Shea, M Tracie
AU  - Shea MT
FAU - Keller, Martin B
AU  - Keller MB
LA  - eng
GR  - R01 MH025478/MH/NIMH NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Compr Psychiatry
JT  - Comprehensive psychiatry
JID - 0372612
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Comorbidity
MH  - Demography
MH  - Depressive Disorder, Major/diagnosis/epidemiology/*psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Personality Disorders/diagnosis/epidemiology
MH  - Prospective Studies
MH  - Psychological Tests
MH  - Psychology
MH  - Recurrence
MH  - Severity of Illness Index
MH  - *Social Behavior
EDAT- 2004/11/05 09:00
MHDA- 2005/03/04 09:00
CRDT- 2004/11/05 09:00
PHST- 2004/11/05 09:00 [pubmed]
PHST- 2005/03/04 09:00 [medline]
PHST- 2004/11/05 09:00 [entrez]
AID - S0010440X04000823 [pii]
AID - 10.1016/j.comppsych.2004.07.002 [doi]
PST - ppublish
SO  - Compr Psychiatry. 2004 Nov-Dec;45(6):423-30. doi: 
      10.1016/j.comppsych.2004.07.002.