PMID- 15526509
OWN - NLM
STAT- MEDLINE
DCOM- 20041209
LR  - 20061115
IS  - 1220-4749 (Print)
IS  - 1220-4749 (Linking)
VI  - 41
IP  - 3
DP  - 2003
TI  - Correlation between the immunophenotypical presentation of dendritic cells and 
      the clinical response to anti-rheumatic treatment in rheumatoid arthritis.
PG  - 255-67
AB  - BACKGROUND: Dendritic cells (DCs) are potent antigen-presenting cells (APC) that 
      are deeply implicated in the initiation and exacerbation of rheumatoid arthritis 
      (RA). Active RA is associated with an activated DCs population as demonstrated by 
      high expression of adhesion and co-stimulatory molecules. PURPOSE: To compare the 
      expression of adhesion and co-stimulatory molecules on DCs from synovial tissue 
      (ST) in patients (pts) with RA and the clinical status before and after treatment 
      with disease modifying antirheumatic drugs (DMARDs). METHODS: Samples of ST were 
      obtained from RA patients at the time of hip or knee replacement or arthroscopy. 
      Clinical status (assessed by the American College of Rheumatology - ACR - core 
      set and the DAS28) and co-stimulatory and adhesion molecules on DCs were 
      evaluated before and after treatment. Immunophenotype of DCs was analyzed by 
      two-color immunofluorescence microscopy. RESULTS: In patients with active RA we 
      found a highly differentiated subpopulation of DCs that expressed an activated 
      phenotype. After treatment, the expression of adhesion and co-stimulatory 
      molecules on ST DCs was correlated with the ACR and DAS28 clinical response. 
      CONCLUSION: Clinical outcome and the immunophenotypical presentation of ST DCs 
      after DMARDs treatment are closely correlated in pts with RA. The co-stimulatory 
      activity in the synovium is important in determining the course of the disease 
      and provide new therapeutic targets for immune intervention.
FAU - Balanescu, Andra
AU  - Balanescu A
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. 
      balanescuandra@hotmail.com
FAU - Nat, Roxana
AU  - Nat R
FAU - Regalia, T
AU  - Regalia T
FAU - Radu, E
AU  - Radu E
FAU - Bojinca, Violeta
AU  - Bojinca V
FAU - Ionescu, Ruxandra
AU  - Ionescu R
FAU - Predescu, V
AU  - Predescu V
FAU - Popescu, E
AU  - Popescu E
FAU - Predeteanu, Denisa
AU  - Predeteanu D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Rom J Intern Med
JT  - Romanian journal of internal medicine = Revue roumaine de medecine interne
JID - 9304507
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antirheumatic Agents/pharmacology/*therapeutic use
MH  - Arthritis, Rheumatoid/*drug therapy/*immunology
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Synovial Membrane/drug effects/immunology
MH  - Treatment Outcome
EDAT- 2004/11/06 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/11/06 09:00
PHST- 2004/11/06 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/11/06 09:00 [entrez]
PST - ppublish
SO  - Rom J Intern Med. 2003;41(3):255-67.