PMID- 15526524
OWN - NLM
STAT- MEDLINE
DCOM- 20041130
LR  - 20131121
IS  - 1220-4749 (Print)
IS  - 1220-4749 (Linking)
VI  - 41
IP  - 4
DP  - 2003
TI  - Study of total homocyst(e)ine levels in type 2 diabetic patients with silent 
      brain infarction.
PG  - 417-31
AB  - Hyperhomocysteinemia is thought to have an important role in the pathogenesis of 
      ischemic cerebral infarction. When associated with diabetes mellitus, it might 
      worsen the neurologic course. The aim of the study was to clarify the relation 
      between plasma homocysteine (Hcy) concentrations and silent brain infarction 
      (SBI) in patients with type 2 diabetes mellitus. Total plasma Hcy levels were 
      prospectively studied in 46 patients with type 2 diabetes and SBI (group I), mean 
      age 56+/-5.4 years, as compared to 38 diabetic patients without SBI (group II) 
      and with 31 controls (group III). Homocysteine concentrations were determined 
      using a high-performance liquid chromatography assay. The results were compared 
      using the Student's t test. The mean level of Hcy was 22.6+/-2.4 micromol/l in 
      group I, 19.7+/-1.6 micromol/l in group II and 11.4+/-1.4 micromol/l in group 
      III; between group I and group II p < or = 0.001. These data are consistent with 
      increased Hcy levels in type 2 diabetic patients, contributing to the onset of 
      SBI in some patients. The phenomenon should be considered in any future strategy 
      for the therapy of hyperhomocyst(e)inemia (HHcy).
FAU - Cojocaru, Inimioara Mihaela
AU  - Cojocaru IM
AD  - Carol Davila University of Medicine and Pharmacy and Clinic of Neurology, 
      Colentina Clinical Hospital, Bucharest, Romania. mcojocaru@cmb.ro
FAU - Uscatescu, Valentina
AU  - Uscatescu V
FAU - Musuroi, Camelia
AU  - Musuroi C
FAU - Botezat, Mihaela
AU  - Botezat M
FAU - Oprisan, Alexandra
AU  - Oprisan A
FAU - Druta, Alina
AU  - Druta A
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Rom J Intern Med
JT  - Romanian journal of internal medicine = Revue roumaine de medecine interne
JID - 9304507
RN  - 0 (Reactive Oxygen Species)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Cerebral Infarction/*blood/physiopathology
MH  - Cerebral Ventricles/pathology
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Angiopathies/*blood/physiopathology
MH  - Endothelium, Vascular/physiology
MH  - Female
MH  - Homocysteine/*blood/metabolism/physiology
MH  - Humans
MH  - Lipid Peroxidation/physiology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reactive Oxygen Species/metabolism
EDAT- 2004/11/06 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/11/06 09:00
PHST- 2004/11/06 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/11/06 09:00 [entrez]
PST - ppublish
SO  - Rom J Intern Med. 2003;41(4):417-31.