PMID- 15528097
OWN - NLM
STAT- MEDLINE
DCOM- 20050119
LR  - 20220330
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 23
IP  - 3
DP  - 2004 Nov
TI  - Brain activation associated with evaluative processes of guilt and embarrassment: 
      an fMRI study.
PG  - 967-74
AB  - We aimed to investigate the neural substrates associated with evaluative process 
      of moral emotions. Using functional magnetic resonance imaging (fMRI), we 
      examined the similarities and differences between evaluative process of guilt and 
      that of embarrassment at the neural basis level. Study of the neural basis of 
      judgments of moral emotions might contribute to a better understanding of the 
      amoral behavior observed in neurological and psychiatric disorders. Nineteen 
      healthy volunteers were studied. The participants read sentences carrying 
      neutral, guilty, or embarrassing contents during the scans. Both guilt and 
      embarrassment conditions commonly activated the medial prefrontal cortex (MPFC), 
      left posterior superior temporal sulcus (STS), and visual cortex. Compared to 
      guilt condition, embarrassment condition produced greater activation in the right 
      temporal cortex (anterior), bilateral hippocampus, and visual cortex. Most of 
      these regions have been implicated in the neural substrate of social cognition or 
      Theory of Mind (ToM). Our results support the idea that both are self-conscious 
      emotions, which are social emotions requiring the ability to represent the mental 
      states of others. At the same time, our functional fMRI data are in favor of the 
      notion that evaluative process of embarrassment might be a more complex process 
      than that of guilt.
FAU - Takahashi, Hidehiko
AU  - Takahashi H
AD  - Section of Psychiatry and Behavioral Science, Graduate School of Medicine, Tokyo 
      Medical and Dental University, Japan.
FAU - Yahata, Noriaki
AU  - Yahata N
FAU - Koeda, Michihiko
AU  - Koeda M
FAU - Matsuda, Tetsuya
AU  - Matsuda T
FAU - Asai, Kunihiko
AU  - Asai K
FAU - Okubo, Yoshiro
AU  - Okubo Y
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - Emotions/*physiology
MH  - Female
MH  - *Guilt
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Linear Models
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Regression Analysis
MH  - Social Perception
MH  - Temporal Lobe/physiology
EDAT- 2004/11/06 09:00
MHDA- 2005/01/20 09:00
CRDT- 2004/11/06 09:00
PHST- 2004/01/21 00:00 [received]
PHST- 2004/06/05 00:00 [revised]
PHST- 2004/07/19 00:00 [accepted]
PHST- 2004/11/06 09:00 [pubmed]
PHST- 2005/01/20 09:00 [medline]
PHST- 2004/11/06 09:00 [entrez]
AID - S1053-8119(04)00428-8 [pii]
AID - 10.1016/j.neuroimage.2004.07.054 [doi]
PST - ppublish
SO  - Neuroimage. 2004 Nov;23(3):967-74. doi: 10.1016/j.neuroimage.2004.07.054.