PMID- 15528134
OWN - NLM
STAT- MEDLINE
DCOM- 20050406
LR  - 20071115
IS  - 1079-9796 (Print)
IS  - 1079-9796 (Linking)
VI  - 33
IP  - 3
DP  - 2004 Nov-Dec
TI  - Alloreactive natural killer cells in mismatched hematopoietic stem cell 
      transplantation.
PG  - 216-21
AB  - Natural killer (NK) cell-mediated, donor-vs.-recipient alloresponses occur 
      following transplantation of human leukocyte antigen (HLA) haplotype-mismatched 
      hematopoietic stem cells (HSCs). NK cell alloreactivity reduced the risk of 
      relapse in acute myeloid leukemia patients while improving engraftment and 
      protecting against graft-vs.-host disease (GvHD). NK cells are primed to kill by 
      several activating receptors. NK killing of autologous cells is prevented because 
      NK cells co-express inhibitory receptors (killer cell Ig-like receptors, KIR) 
      that recognize groups of (self) MHC class I alleles. As KIRs are clonally 
      distributed, the NK population in any individual is constituted of a repertoire 
      with different allospecificities. NK cells in the repertoire mediate 
      alloreactions when the allogeneic targets do not express class I alleles that 
      block them. High resolution molecular HLA typing of recipient and donor, positive 
      identification of donor KIR genes, and in some cases, functional assessment of 
      donor NK clones will identify haploidentical donors who are able to mount 
      donor-vs.-recipient NK alloreactions.
FAU - Ruggeri, Loredana
AU  - Ruggeri L
AD  - Department of Clinical and Experimental Medicine, Haematology and Clinical 
      Immunology, University of Perugia, Italy.
FAU - Capanni, Marusca
AU  - Capanni M
FAU - Mancusi, Antonella
AU  - Mancusi A
FAU - Urbani, Elena
AU  - Urbani E
FAU - Perruccio, Katia
AU  - Perruccio K
FAU - Burchielli, Emanuela
AU  - Burchielli E
FAU - Tosti, Antonella
AU  - Tosti A
FAU - Topini, Fabiana
AU  - Topini F
FAU - Aversa, Franco
AU  - Aversa F
FAU - Martelli, Massimo F
AU  - Martelli MF
FAU - Velardi, Andrea
AU  - Velardi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Blood Cells Mol Dis
JT  - Blood cells, molecules & diseases
JID - 9509932
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Animals
MH  - Graft vs Leukemia Effect/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Antigens Class I/immunology
MH  - *Histocompatibility Testing
MH  - Host vs Graft Reaction/immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Leukemia, Myeloid, Acute/*immunology/therapy
MH  - Transplantation, Homologous
RF  - 24
EDAT- 2004/11/06 09:00
MHDA- 2005/04/07 09:00
CRDT- 2004/11/06 09:00
PHST- 2004/08/03 00:00 [received]
PHST- 2004/11/06 09:00 [pubmed]
PHST- 2005/04/07 09:00 [medline]
PHST- 2004/11/06 09:00 [entrez]
AID - S1079-9796(04)00164-0 [pii]
AID - 10.1016/j.bcmd.2004.08.005 [doi]
PST - ppublish
SO  - Blood Cells Mol Dis. 2004 Nov-Dec;33(3):216-21. doi: 10.1016/j.bcmd.2004.08.005.