PMID- 15528768
OWN - NLM
STAT- MEDLINE
DCOM- 20041230
LR  - 20190513
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 59
IP  - 10
DP  - 2004 Oct
TI  - Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca 
      fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year 
      intervention trial.
PG  - 1007-14
AB  - Caloric restriction (CR) retards aging processes, extends maximal life span, and 
      consistently improves insulin resistance in lower species. Insulin resistance is 
      associated with cardiovascular disease, but data is lacking demonstrating that 
      increased insulin sensitivity reduces atherosclerosis progression. We initiated a 
      study in 32 adult cynomolgus monkeys to evaluate increased insulin sensitivity 
      secondary to CR on atherosclerosis extent. Following pretrial determinations, 
      animals were randomized to a moderately atherogenic (0.25 mg cholesterol/Cal 
      containing 30% of calories from fat)-fed control group or CR group (30% 
      reduction) with equivalent dietary cholesterol intake. CR significantly improved 
      insulin sensitivity and reduced intraabdominal fat over the 4-year intervention, 
      while no significant differences were seen for the lipid profile between groups. 
      Despite improved insulin sensitivity with CR, atherosclerosis extent did not 
      differ between the ad libitum-fed or CR groups. These studies demonstrate that CR 
      significantly improves insulin sensitivity, but when elevated plasma cholesterol 
      concentrations were held similar, there was no effect on atherosclerosis extent. 
      However, the composition of these lesions and changes in endothelial function may 
      have been improved but were not evaluated in this study. Thus, further studies 
      are needed to determine if improved insulin sensitivity might decrease arterial 
      inflammation and improve endothelial function, despite no changes in 
      atherosclerosis extent.
FAU - Cefalu, William T
AU  - Cefalu WT
AD  - Division of Nutrition and Chronic Diseases, Pennington Biomedical Research 
      Center, Louisiana State University, Baton Rouge 70808, USA. cefaluwt@pbrc.edu
FAU - Wang, Zhong Q
AU  - Wang ZQ
FAU - Bell-Farrow, Audrey D
AU  - Bell-Farrow AD
FAU - Collins, Joel
AU  - Collins J
FAU - Morgan, Timothy
AU  - Morgan T
FAU - Wagner, Janice D
AU  - Wagner JD
LA  - eng
GR  - AG000578/AG/NIA NIH HHS/United States
GR  - AG0180816/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Abdomen
MH  - Adipose Tissue/diagnostic imaging
MH  - Aging/blood/*metabolism
MH  - Animals
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Cardiovascular System/*growth & development
MH  - Cholesterol/blood
MH  - Coronary Artery Disease/blood/*physiopathology
MH  - Disease Progression
MH  - Energy Intake
MH  - Insulin/metabolism
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Lipoproteins/blood
MH  - Macaca fascicularis
MH  - Male
MH  - Osmolar Concentration
MH  - Random Allocation
MH  - Tomography, X-Ray Computed
EDAT- 2004/11/06 09:00
MHDA- 2004/12/31 09:00
CRDT- 2004/11/06 09:00
PHST- 2004/11/06 09:00 [pubmed]
PHST- 2004/12/31 09:00 [medline]
PHST- 2004/11/06 09:00 [entrez]
AID - 59/10/B1007 [pii]
AID - 10.1093/gerona/59.10.b1007 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2004 Oct;59(10):1007-14. doi: 
      10.1093/gerona/59.10.b1007.