PMID- 15530835 OWN - NLM STAT- MEDLINE DCOM- 20050106 LR - 20051116 IS - 1471-4906 (Print) IS - 1471-4906 (Linking) VI - 25 IP - 12 DP - 2004 Dec TI - Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity. PG - 655-8 AB - Dendritic cells (DCs) consist of a heterogeneous collection of subsets, many with unique phenotypic and functional characteristics. Although certain subsets migrate from peripheral non-lymphoid tissues, there is evidence that antigen presentation can extend to DCs that permanently reside within the lymph node. This Opinion describes this finding in the context of antigen transfer between migrating and lymphoid-resident DCs in cases of T-cell priming and tolerance induction. FAU - Carbone, Francis R AU - Carbone FR AD - The Department of Microbiology and Immunology, The University of Melbourne, Parkville 3010, Victoria, Australia. fcarbone@unimelb.edu.au FAU - Belz, Gabrielle T AU - Belz GT FAU - Heath, William R AU - Heath WR LA - eng PT - Journal Article PT - Review PL - England TA - Trends Immunol JT - Trends in immunology JID - 100966032 SB - IM MH - Animals MH - Antigen Presentation MH - CD8-Positive T-Lymphocytes/immunology MH - Cell Movement MH - Dendritic Cells/classification/cytology/*immunology MH - Herpes Simplex/immunology MH - Humans MH - Immune Tolerance MH - Langerhans Cells/cytology/immunology MH - Lymph Nodes/cytology/immunology MH - Models, Immunological RF - 40 EDAT- 2004/11/09 09:00 MHDA- 2005/01/07 09:00 CRDT- 2004/11/09 09:00 PHST- 2004/11/09 09:00 [pubmed] PHST- 2005/01/07 09:00 [medline] PHST- 2004/11/09 09:00 [entrez] AID - S1471-4906(04)00293-5 [pii] AID - 10.1016/j.it.2004.09.013 [doi] PST - ppublish SO - Trends Immunol. 2004 Dec;25(12):655-8. doi: 10.1016/j.it.2004.09.013.