PMID- 15531546
OWN - NLM
STAT- MEDLINE
DCOM- 20041202
LR  - 20171116
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 89
IP  - 11
DP  - 2004 Nov
TI  - Thyroid fetal male microchimerisms in mothers with thyroid disorders: presence of 
      Y-chromosomal immunofluorescence in thyroid-infiltrating lymphocytes is more 
      prevalent in Hashimoto's thyroiditis and Graves' disease than in follicular 
      adenomas.
PG  - 5810-4
AB  - The presence of fetal cells in a maternal compartment is defined as 
      fetal-maternal microchimerism, which has been detected in thyroids of mothers 
      suffering from autoimmunity. We analyzed the immunohistology of paraffin-embedded 
      thyroid specimen taken at surgery from 49 women with Hashimoto's thyroiditis (n = 
      25), Graves' disease (n = 15), or nodular or diffuse follicular adenomas (n = 9), 
      whose childbirth history was positive for sons. By fluorescence in situ 
      hybridization we screened for X-chromosome- and Y-chromosome-specific staining 
      and compared the finding with human leukocyte antigen (HLA) DQ types of the 
      mothers and, where available, their offspring. In 23 thyroids we found 
      Y-chromosome-specific staining, which was more frequent in thyroid autoimmune 
      disease (60% Hashimoto's thyroiditis and 40% Graves' disease) than in follicular 
      adenomas (22.2%). There was no significant difference for HLA DQ alleles among 
      women whose thyroids showed Y-chromosome staining and those without. However, a 
      subgroup of all investigated microchimerism-positive mother-child pairs and women 
      with Hashimoto's thyroiditis and Graves' disease more often had the 
      susceptibility alleles HLA DQA1*0501-DQB1*0201 or DQB1*0301. In conclusion, fetal 
      microchimerism is observed in thyroids of mothers with sons, and this is found 
      more frequently in thyroid autoimmune diseases.
FAU - Renne, Christoph
AU  - Renne C
AD  - Institute of Pathology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 
      D-60596 Frankfurt am Main, Germany.
FAU - Ramos Lopez, Elizabeth
AU  - Ramos Lopez E
FAU - Steimle-Grauer, Susanne A
AU  - Steimle-Grauer SA
FAU - Ziolkowski, Piotr
AU  - Ziolkowski P
FAU - Pani, Michael A
AU  - Pani MA
FAU - Luther, Christina
AU  - Luther C
FAU - Holzer, Katharina
AU  - Holzer K
FAU - Encke, Albrecht
AU  - Encke A
FAU - Wahl, Robert A
AU  - Wahl RA
FAU - Bechstein, Wolf O
AU  - Bechstein WO
FAU - Usadel, Klaus H
AU  - Usadel KH
FAU - Hansmann, Martin-Leo
AU  - Hansmann ML
FAU - Badenhoop, Klaus
AU  - Badenhoop K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Antigens, CD20)
RN  - 0 (CD3 Complex)
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adenoma/*genetics/pathology
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Antigens, CD20/analysis
MH  - CD3 Complex/analysis
MH  - Chimera
MH  - *Chromosomes, Human, Y
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Graves Disease/*genetics/pathology
MH  - HLA-DQ Antigens/genetics
MH  - Humans
MH  - Lymphocytes/*ultrastructure
MH  - Male
MH  - Middle Aged
MH  - Pregnancy
MH  - Retrospective Studies
MH  - Thyroid Diseases/*genetics/pathology
MH  - Thyroid Gland/*pathology
MH  - Thyroiditis, Autoimmune/*genetics/pathology
EDAT- 2004/11/09 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/11/09 09:00
PHST- 2004/11/09 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/11/09 09:00 [entrez]
AID - 89/11/5810 [pii]
AID - 10.1210/jc.2004-1049 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2004 Nov;89(11):5810-4. doi: 10.1210/jc.2004-1049.