PMID- 15531903
OWN - NLM
STAT- MEDLINE
DCOM- 20050519
LR  - 20041216
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 35
IP  - 1
DP  - 2005 Jan
TI  - Impact of HLA class I high-resolution mismatches on chronic graft-versus-host 
      disease and survival of patients given hematopoietic stem cell grafts from 
      unrelated donors.
PG  - 57-62
AB  - There is consensus that matching of unrelated donors (URD) and patients for HLA 
      class II alleles improves the outcome of hematopoietic stem cell transplantation 
      (HSCT). However, the significance of HLA class I allelic mismatches for 
      transplant outcome is under discussion and reports on long-term effects like 
      chronic graft-versus-host disease (GVHD) are rare. Thus, we investigated the 
      association of human leukocyte antigen (HLA) class I allele mismatches and 
      outcome in 144 patients given HSCT from URD who were matched for HLA-DRB1, 
      DRB3/4/5, and DQB1 alleles. The risk of chronic GVHD was significantly increased 
      in patients with class I mismatched donors, the mismatch either detected by low- 
      or high-resolution typing. A single HLA class I allele mismatch significantly 
      increased the risk of chronic GVHD in multivariate analysis. Overall survival was 
      significantly reduced in patient/donor pairs with more than one-allele class I 
      mismatch. Thus, selection of unrelated donors for transplantation should be based 
      on high-resolution HLA class I typing.
FAU - Greinix, H T
AU  - Greinix HT
AD  - Department of Medicine I, Bone Marrow Transplantation, Medical University of 
      Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. 
      hildegard.greinix@meduniwien.ac.at
FAU - Fae, I
AU  - Fae I
FAU - Schneider, B
AU  - Schneider B
FAU - Rosenmayr, A
AU  - Rosenmayr A
FAU - Mitterschiffthaler, A
AU  - Mitterschiffthaler A
FAU - Pelzmann, B
AU  - Pelzmann B
FAU - Kalhs, P
AU  - Kalhs P
FAU - Lechner, K
AU  - Lechner K
FAU - Mayr, W R
AU  - Mayr WR
FAU - Fischer, G F
AU  - Fischer GF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Blood Donors
MH  - Blood Group Incompatibility
MH  - Female
MH  - Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - Graft Survival
MH  - *Graft vs Host Disease
MH  - HLA Antigens/*biosynthesis
MH  - Hematologic Neoplasms/mortality/therapy
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Hematopoietic Stem Cells/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2004/11/09 09:00
MHDA- 2005/05/20 09:00
CRDT- 2004/11/09 09:00
PHST- 2004/11/09 09:00 [pubmed]
PHST- 2005/05/20 09:00 [medline]
PHST- 2004/11/09 09:00 [entrez]
AID - 1704741 [pii]
AID - 10.1038/sj.bmt.1704741 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2005 Jan;35(1):57-62. doi: 10.1038/sj.bmt.1704741.