PMID- 15532882
OWN - NLM
STAT- MEDLINE
DCOM- 20041202
LR  - 20240314
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 45
IP  - 10
DP  - 2004 Oct
TI  - Evaluation of oxidative stress markers for the early diagnosis of allograft 
      rejection in feline renal allotransplant recipients with normal renal function.
PG  - 831-7
AB  - The purpose of this study was to identify oxidative damage to renal allografts 
      during graft rejection by evaluating changes in oxidative markers and plasma 
      lactate levels in feline renal allotransplant recipients. Heterotopic renal 
      allotransplantations were performed between 8 adult feline cross-matched donors. 
      Following 14 d of immunosuppression, the drugs were discontinued to allow 
      allograft rejection. Baseline and serial postoperative evaluations of serum 
      creatinine, plasma lactate, plasma thiobarbituate reactive substances (TBARS), 
      plasma creatol, urine creatol, and renal sonographic cross-sectional area were 
      performed. When sonographic evaluation revealed the absence of blood flow to the 
      allograft, the rejected kidney was nephrectomized and evaluated 
      histopathologically. Allograft rejection occurred in all cats by day 26. A 
      significant elevation in body temperature occurred during the rejection period. 
      No significant change was observed between any of the time periods for plasma 
      TBARS, creatol, or urine creatol. There was a significant decrease in plasma 
      lactate levels throughout the study. Markers of oxidative stress from venous 
      blood did not reflect renal allograft rejection in cats with a normally 
      functioning native kidney. Renal allograft rejection may be associated with 
      significant increases in body temperature and warrants further investigation.
FAU - Halling, Krista B
AU  - Halling KB
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine, 
      University of Florida, Gainesville, Florida 32610, USA.
FAU - Ellison, Gary W
AU  - Ellison GW
FAU - Armstrong, Don
AU  - Armstrong D
FAU - Aoyagi, Kasumi
AU  - Aoyagi K
FAU - Detrisac, Carol J
AU  - Detrisac CJ
FAU - Graham, John P
AU  - Graham JP
FAU - Newell, Susan P
AU  - Newell SP
FAU - Martin, Frank G
AU  - Martin FG
FAU - Van Gilder, James M
AU  - Van Gilder JM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
RN  - 0 (Biomarkers)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 133882-98-1 (creatol)
RN  - 33X04XA5AT (Lactic Acid)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Cat Diseases/surgery
MH  - Cats
MH  - Creatinine/*analogs & derivatives/*blood/urine
MH  - Fever/veterinary
MH  - Graft Rejection/blood/diagnosis/*veterinary
MH  - Kidney/blood supply/diagnostic imaging
MH  - Kidney Failure, Chronic/surgery/veterinary
MH  - Kidney Function Tests/methods/veterinary
MH  - Kidney Transplantation/*veterinary
MH  - Lactic Acid/blood
MH  - Male
MH  - Oxidative Stress
MH  - Predictive Value of Tests
MH  - Specific Pathogen-Free Organisms
MH  - *Thiobarbituric Acid Reactive Substances
MH  - Ultrasonography
PMC - PMC545987
EDAT- 2004/11/10 09:00
MHDA- 2004/12/16 09:00
PMCR- 2005/01/01
CRDT- 2004/11/10 09:00
PHST- 2004/11/10 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/11/10 09:00 [entrez]
PHST- 2005/01/01 00:00 [pmc-release]
AID - pg831 [pii]
PST - ppublish
SO  - Can Vet J. 2004 Oct;45(10):831-7.