PMID- 15533913
OWN - NLM
STAT- MEDLINE
DCOM- 20050202
LR  - 20061115
IS  - 1055-9965 (Print)
IS  - 1055-9965 (Linking)
VI  - 13
IP  - 11 Pt 1
DP  - 2004 Nov
TI  - Occupational exposure to immunologically active agents and risk for lymphoma.
PG  - 1814-8
AB  - OBJECTIVES: We evaluated whether occupational exposure to high molecular weight 
      agents that are associated with asthma and that act predominantly through an 
      immunoglobulin E (IgE)-dependent hypersensitivity mechanism is also associated 
      with risk for specific lymphoma types. METHODS: The Spanish lymphoma case-control 
      study includes 519 newly diagnosed cases of lymphoid neoplasms and 554 hospital 
      controls ages 20 to 80 years. Lymphomas were histologically or cytologically 
      confirmed and classified according to the WHO classification. Lifetime 
      occupational exposure to seven high molecular weight agents such as latex was 
      evaluated through an asthma-specific job-exposure matrix and validated by an 
      industrial hygienist. Odds ratios (OR) and 95% confidence intervals (95% CI) were 
      adjusted for age, sex, hospital, and occupational exposures. RESULTS: Subjects 
      exposed to high molecular weight agents had an increased risk for Hodgkin's 
      lymphoma (OR, 2.27; 95% CI, 0.93-5.50), particularly nodular sclerosis (OR, 3.22; 
      95% CI, 1.14-9.09). ORs did not increase with duration of exposure to these 
      agents. Exposure to high molecular weight agents was not associated with risk of 
      other B-cell lymphomas; for most specific subcategories of B-cell lymphoma, ORs 
      were below unity. A slightly increased OR (95% CI) was seen for mycosis fungoides 
      [1.60 (0.53-4.84)], although overall there was no increased risk for T-cell 
      lymphomas. CONCLUSIONS: Exposure to immunologically active agents among 
      clinically immunocompetent subjects was associated with risk for Hodgkin's 
      lymphoma.
FAU - Kogevinas, Manolis
AU  - Kogevinas M
AD  - Servei d'Epidemiologia & Registre del Cancer, Institut Catala d'Oncologia, Gran 
      Via Km 2.7, 08907 L'Hospitalet, Barcelona, Spain.
FAU - Zock, Jan-Paul
AU  - Zock JP
FAU - Alvaro, Tomas
AU  - Alvaro T
FAU - Garcia-Villanueva, Mercedes
AU  - Garcia-Villanueva M
FAU - Domingo-Domenech, Eva
AU  - Domingo-Domenech E
FAU - Kennedy, Susan
AU  - Kennedy S
FAU - Martinez-Maza, Otoniel
AU  - Martinez-Maza O
FAU - de Sanjose, Silvia
AU  - de Sanjose S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/chemically induced/immunology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Lymphoma/*chemically induced/epidemiology/immunology
MH  - Male
MH  - Middle Aged
MH  - Molecular Weight
MH  - Occupational Exposure/*adverse effects
MH  - Risk Factors
MH  - Spain/epidemiology
EDAT- 2004/11/10 09:00
MHDA- 2005/02/03 09:00
CRDT- 2004/11/10 09:00
PHST- 2004/11/10 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/11/10 09:00 [entrez]
AID - 13/11/1814 [pii]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2004 Nov;13(11 Pt 1):1814-8.