PMID- 15534563
OWN - NLM
STAT- MEDLINE
DCOM- 20050105
LR  - 20211203
IS  - 1462-0308 (Print)
IS  - 1462-0308 (Linking)
VI  - 9
IP  - 3
DP  - 2004 Sep
TI  - HIV and human leukocyte antigen association--the Indian scenario.
PG  - 60-4
AB  - Genetic factors such as human leukocyte antigen (HLA) affect the infection and 
      progression of HIV disease. The dependence of effective cytotoxic T lymphocyte 
      (CTL) activity on HIV-specific T-helper responses has become increasingly evident 
      and studies provide strong evidence that T-helper responses and the magnitude of 
      CTL responses are closely linked. HLA haplotype A11-B35-Cw4 has been associated 
      with rapid progression of AIDS. Our earlier studies had shown that HLA B*3520, 
      B*1801 and Cw*1507 alleles were associated in western Indian HIV-1-infected AIDS 
      patients. Further, it was observed that A*110101-B*3520-Cw*1507 haplotype was 
      significantly increased among the AIDS patients. I compiled the frequency of 
      these alleles and their molecular subtype distribution from 4333 individuals from 
      India. The results showed that these high-risk alleles and their subtypes were 
      significantly increased among selected castes or population groups (breeding 
      isolates living in the plains) but lower in tribal groups (breeding isolates 
      living in the hills), which revealed a high genetic diversity among Indians. My 
      analysis shows that the genetic susceptibility and HLA allelic immune response 
      among the HIV-infected AIDS individuals in India are different.
FAU - Shankarkumar, Umapathy
AU  - Shankarkumar U
AD  - HLA Department, Institute of Immunohaematology (ICMR), 13th Floor, KEM Hospital, 
      Parel, Mumbai 400 012, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J HIV Ther
JT  - Journal of HIV therapy
JID - 101088049
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Disease Susceptibility
MH  - Ethnicity
MH  - Genetic Variation/immunology
MH  - HIV Infections/*genetics/*immunology
MH  - HIV-1/*immunology
MH  - HLA Antigens/*genetics/*immunology
MH  - Haplotypes/genetics
MH  - Humans
MH  - India
RF  - 21
EDAT- 2004/11/10 09:00
MHDA- 2005/01/06 09:00
CRDT- 2004/11/10 09:00
PHST- 2004/11/10 09:00 [pubmed]
PHST- 2005/01/06 09:00 [medline]
PHST- 2004/11/10 09:00 [entrez]
PST - ppublish
SO  - J HIV Ther. 2004 Sep;9(3):60-4.