PMID- 15537675
OWN - NLM
STAT- MEDLINE
DCOM- 20050725
LR  - 20061115
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 15
IP  - 7
DP  - 2005 Jul
TI  - Structural and functional aberrations in the cerebral cortex of tenascin-C 
      deficient mice.
PG  - 950-62
AB  - The extracellular matrix glycoprotein tenascin-C (TNC) has been implicated in 
      neural development and plasticity but many of its functions in vivo remain 
      obscure. Here we addressed the question as to whether the constitutive absence of 
      TNC in mice affects cortical physiology and structure. Defined major cell 
      populations (neurons and inhibitory neuronal subpopulations, astrocytes, 
      oligodendrocytes and microglia) were quantified in the somatosensory and motor 
      cortices of adult TNC deficient (TNC-/-) and wild-type (TNC+/+) mice by 
      immunofluorescence labelling and stereology. In both areas studied we found 
      abnormally high neuronal density, astrogliosis, low density of 
      parvalbumin-positive interneurons and reduced ratios of oligodendrocytes to 
      neurons and of inhibitory to excitatory neurons in the TNC deficient as opposed 
      to the non-deficient animals. Analysis of Golgi-impregnated layer V pyramidal 
      neurons in TNC-/- animals showed aberrant dendrite tortuosity and redistribution 
      of stubby spines within first- to third-order dendritic arbors. Significantly 
      enhanced responses upon whisker stimulation were recorded epicranially over the 
      barrel and the motor cortices of TNC-/- as compared to TNC+/+ animals, and this 
      effect might be associated with the diminished inhibitory circuitry. These 
      results indicate that TNC is essential for normal cortical development and 
      function.
FAU - Irintchev, Andrey
AU  - Irintchev A
AD  - Zentrum fur Molekulare Neurobiologie, Universitat Hamburg, D-20246 Hamburg, 
      Germany.
FAU - Rollenhagen, Astrid
AU  - Rollenhagen A
FAU - Troncoso, Edgardo
AU  - Troncoso E
FAU - Kiss, Jozsef Z
AU  - Kiss JZ
FAU - Schachner, Melitta
AU  - Schachner M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20041110
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Tenascin)
SB  - IM
MH  - Animals
MH  - Cell Count
MH  - Dendritic Spines/pathology
MH  - Evoked Potentials, Somatosensory
MH  - Female
MH  - Interneurons/pathology/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Motor Cortex/*abnormalities/pathology/*physiopathology
MH  - Neural Inhibition
MH  - Neuroglia/pathology
MH  - Pyramidal Cells/pathology/ultrastructure
MH  - Somatosensory Cortex/*abnormalities/pathology/*physiopathology
MH  - Tenascin/*genetics
MH  - Vibrissae/innervation/physiology
EDAT- 2004/11/13 09:00
MHDA- 2005/07/26 09:00
CRDT- 2004/11/13 09:00
PHST- 2004/11/13 09:00 [pubmed]
PHST- 2005/07/26 09:00 [medline]
PHST- 2004/11/13 09:00 [entrez]
AID - bhh195 [pii]
AID - 10.1093/cercor/bhh195 [doi]
PST - ppublish
SO  - Cereb Cortex. 2005 Jul;15(7):950-62. doi: 10.1093/cercor/bhh195. Epub 2004 Nov 
      10.