PMID- 15538591
OWN - NLM
STAT- MEDLINE
DCOM- 20050606
LR  - 20221207
IS  - 0940-1334 (Print)
IS  - 0940-1334 (Linking)
VI  - 255
IP  - 1
DP  - 2005 Feb
TI  - Clinical outcome in patients with obsessive-compulsive disorder after 
      discontinuation of SRI treatment: results from a two-year follow-up.
PG  - 48-50
AB  - BACKGROUND: Combined treatment with serotonin-reuptake inhibitors (SRI) and 
      cognitive-behavioral therapy (CBT) is a common therapy approach for 
      obsessive-compulsive disorder (OCD). However, it is a matter of debate whether 
      discontinuation of SRI after combined treatment leads to relapse. METHOD: 
      Seventy-four consecutively admitted patients suffering from OCD were included in 
      the study. Thirty-seven patients were treated with CBT alone, and 37 patients 
      received combined CBT and SRI treatment. Of these latter patients, seventeen 
      discontinued SRI treatment during the follow-up period (1 and 2 years after 
      inpatient treatment). OCD symptom severity was determined by Yale-Brown Obsessive 
      Compulsive Scale (Y-BOCS), and mood was assessed by Hamilton Depression Rating 
      Scale (HDRS). RESULTS: During the initial treatment, scores for Y-BOCS (p < 
      0.001), HDRS (p < 0.001) and the Global Assessment of Functioning Scale (GAF) (p 
      < 0.001) improved significantly in all groups. Reassessment two years later 
      revealed that a) OCD symptom severity and depression scores were similar between 
      the groups and b) discontinuation of SRI did not prompt by a recurrence of 
      symptoms. CONCLUSIONS: We interpret our results as suggesting that 
      discontinuation of SRI treatment may be considered in formerly combined treated 
      OCD patients after stable remission.
FAU - Kordon, Andreas
AU  - Kordon A
AD  - Universitaetsklinikum Schleswig-Holstein, Campus Luebeck, Klinik fuer Psychiatrie 
      und Psychotherapie, Ratzeburger Allee 160, 23538 Luebeck, Germany. 
      kordon.a@psychiatry.uni-luebeck.de
FAU - Kahl, Kai G
AU  - Kahl KG
FAU - Broocks, Andreas
AU  - Broocks A
FAU - Voderholzer, Ulrich
AU  - Voderholzer U
FAU - Rasche-Rauchle, Hildegard
AU  - Rasche-Rauchle H
FAU - Hohagen, Fritz
AU  - Hohagen F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20041112
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (Serotonin Uptake Inhibitors)
SB  - IM
MH  - Adult
MH  - Cognitive Behavioral Therapy/*methods
MH  - Combined Modality Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - Obsessive-Compulsive Disorder/*therapy
MH  - Psychiatric Status Rating Scales
MH  - Selective Serotonin Reuptake Inhibitors/*therapeutic use
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2004/11/13 09:00
MHDA- 2005/06/07 09:00
CRDT- 2004/11/13 09:00
PHST- 2003/12/23 00:00 [received]
PHST- 2004/05/10 00:00 [accepted]
PHST- 2004/11/13 09:00 [pubmed]
PHST- 2005/06/07 09:00 [medline]
PHST- 2004/11/13 09:00 [entrez]
AID - 10.1007/s00406-004-0533-y [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2005 Feb;255(1):48-50. doi: 
      10.1007/s00406-004-0533-y. Epub 2004 Nov 12.