PMID- 15539769
OWN - NLM
STAT- MEDLINE
DCOM- 20050607
LR  - 20131121
IS  - 0006-3126 (Print)
IS  - 0006-3126 (Linking)
VI  - 87
IP  - 2
DP  - 2005
TI  - Antioxidant status of neonates exposed in utero to tobacco smoke.
PG  - 121-6
AB  - To investigate the influence of maternal smoke exposure on neonatal and maternal 
      antioxidant status, 39 mothers who were active smokers, 14 mothers exposed to 
      environmental tobacco smoke (ETS), 17 controls, and their newborns were included 
      in a prospective, controlled study. Plasma total antioxidant capacity, measured 
      as total radical-trapping antioxidant parameter (TRAP) and ferric reducing 
      antioxidant power (FRAP), and concentrations of specific antioxidants were 
      measured in cord and in maternal blood. A similar, significant increase in 
      ceruloplasmin concentration was observed in neonates born to actively smoking 
      mothers and in those born to ETS exposed mothers. Uric acid and TRAP 
      concentrations were significantly increased in ETS-exposed newborns and their 
      mothers, compared to newborns and mothers from the active smoking and no-exposure 
      groups with a trend towards increased uric acid, TRAP and FRAP concentrations 
      being observed in the active smokers group. Neonatal and maternal antioxidant 
      concentrations correlated significantly, except for ceruloplasmin. Cord blood 
      vitamin A, E and C concentrations were unaffected by smoke exposure. These 
      results show that maternal active smoking as well as ETS exposure significantly 
      affect neonatal and maternal antioxidant status.
CI  - Copyright (c) 2005 S. Karger AG, Basel
FAU - Fayol, L
AU  - Fayol L
AD  - Departement de Neonatologie, Assistance Publique, Hopitaux de Marseille-Hopital 
      de La Timone, 264, rue Saint-Pierre, FR-13005 Marseille, France.
FAU - Gulian, J M
AU  - Gulian JM
FAU - Dalmasso, C
AU  - Dalmasso C
FAU - Calaf, R
AU  - Calaf R
FAU - Simeoni, U
AU  - Simeoni U
FAU - Millet, V
AU  - Millet V
LA  - eng
PT  - Journal Article
DEP - 20041112
PL  - Switzerland
TA  - Biol Neonate
JT  - Biology of the neonate
JID - 0247551
RN  - 0 (Antioxidants)
RN  - 0 (Ferric Compounds)
RN  - 0 (Free Radicals)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 11103-57-4 (Vitamin A)
RN  - 1406-18-4 (Vitamin E)
RN  - 268B43MJ25 (Uric Acid)
RN  - EC 1.16.3.1 (Ceruloplasmin)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Adult
MH  - Antioxidants/*analysis
MH  - Ascorbic Acid/blood
MH  - Ceruloplasmin/analysis
MH  - Female
MH  - Ferric Compounds/chemistry
MH  - Fetal Blood/*chemistry
MH  - Free Radicals/chemistry
MH  - Humans
MH  - Infant, Newborn
MH  - *Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Prospective Studies
MH  - Smoking/*adverse effects
MH  - Tobacco Smoke Pollution/*adverse effects
MH  - Uric Acid/blood
MH  - Vitamin A/blood
MH  - Vitamin E/blood
EDAT- 2004/11/13 09:00
MHDA- 2005/06/09 09:00
CRDT- 2004/11/13 09:00
PHST- 2004/02/25 00:00 [received]
PHST- 2004/09/01 00:00 [accepted]
PHST- 2004/11/13 09:00 [pubmed]
PHST- 2005/06/09 09:00 [medline]
PHST- 2004/11/13 09:00 [entrez]
AID - 82128 [pii]
AID - 10.1159/000082128 [doi]
PST - ppublish
SO  - Biol Neonate. 2005;87(2):121-6. doi: 10.1159/000082128. Epub 2004 Nov 12.