PMID- 15541849
OWN - NLM
STAT- MEDLINE
DCOM- 20050408
LR  - 20220408
IS  - 0301-2115 (Print)
IS  - 0301-2115 (Linking)
VI  - 117
IP  - 2
DP  - 2004 Dec 1
TI  - Symmetrical fetal growth retardation after gestational cocaine exposure in the 
      rat.
PG  - 148-53
AB  - Cocaine use during pregnancy results in an increase in different maternal and 
      perinatal complications. The fetal effects of cocaine could be mainly related to 
      the disturbances in the brain development, microcephaly being the most common 
      brain abnormality. The aim of this study was to analyze maternal outcome and 
      fetal somatic effects of cocaine and to evaluate the hypothesis that maternal 
      cocaine exposure would specifically impair fetal global brain development. 
      Fifty-four timed-pregnant female Sprague-Dawley rats were daily injected with 15 
      or 40 mg/kg per day from gestational day (GD) 1 or 8 and sacrificed at 
      gestational day 20. By analyzing different maternal and fetal outcomes, it could 
      be suggested that the cocaine exposure in pregnant rats decreased maternal weight 
      gain without significant maternal mortality, did not affect the mean number of 
      fetuses by litter, although notably increased stillbirths, reduced fetal birth 
      weight, and reduced the fetal central nervous system weight. Present results are 
      globally in agreement with the literature and underline a possible selective 
      effect of cocaine on the fetal CNS resulting in symmetrical intrauterine fetal 
      growth retardation in contrast to the asymmetrical retardation of undernutrition.
FAU - Campillo, F
AU  - Campillo F
AD  - Department of Obstetrics and Gynecology, Hospital Universitario Virgen de la 
      Arrixaca, Murcia, Spain.
FAU - Remezal, M
AU  - Remezal M
FAU - Vez, M D
AU  - Vez MD
FAU - Navarro-Pando, J M
AU  - Navarro-Pando JM
FAU - Perez-Flores, D
AU  - Perez-Flores D
FAU - Parrilla, J J
AU  - Parrilla JJ
FAU - Abad, L
AU  - Abad L
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
RN  - 0 (Central Nervous System Stimulants)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects/embryology
MH  - Central Nervous System/drug effects/embryology
MH  - Central Nervous System Diseases/chemically induced/embryology
MH  - Central Nervous System Stimulants/*adverse effects
MH  - Cocaine/*adverse effects
MH  - Cocaine-Related Disorders/etiology
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Fetal Growth Retardation/*chemically induced
MH  - Fetal Organ Maturity/drug effects
MH  - Models, Animal
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2004/11/16 09:00
MHDA- 2005/04/09 09:00
CRDT- 2004/11/16 09:00
PHST- 2004/01/20 00:00 [received]
PHST- 2004/03/10 00:00 [accepted]
PHST- 2004/11/16 09:00 [pubmed]
PHST- 2005/04/09 09:00 [medline]
PHST- 2004/11/16 09:00 [entrez]
AID - S0301211504001629 [pii]
AID - 10.1016/j.ejogrb.2004.03.004 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2004 Dec 1;117(2):148-53. doi: 
      10.1016/j.ejogrb.2004.03.004.