PMID- 15542251
OWN - NLM
STAT- MEDLINE
DCOM- 20050105
LR  - 20151119
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 372
IP  - 3
DP  - 2004 Dec 6
TI  - Treadmill exercise improves short-term memory by suppressing ischemia-induced 
      apoptosis of neuronal cells in gerbils.
PG  - 256-61
AB  - In the present study, the effect of treadmill exercise on short-term memory, 
      apoptotic neuronal cell death, and cell proliferation in the hippocampal dentate 
      gyrus following transient global ischemia in gerbils was investigated. Step-down 
      inhibitory avoidance task, terminal deoxynucleotidyl transferase-mediated dUTP 
      nick end labeling (TUNEL) assay, and immunohistochemistry for caspase-3 and 
      5-bromo-2'-deoxyuridine (BrdU) were used. Ischemia was induced by the occlusion 
      of both common carotid arteries (CCA) of gerbils for 5 min. Gerbils in exercise 
      groups were forced to run on a treadmill for 30 min once a day for 10 consecutive 
      days. Such treadmill exercise improved short-term memory by suppressing the 
      ischemia-induced apoptotic neuronal cell death in the dentate gyrus. In addition, 
      treadmill running suppressed the ischemia-induced cell proliferation in the 
      dentate gyrus. The present results suggest that treadmill exercise overcomes the 
      ischemia-induced apoptotic neuronal cell death and thus facilitates the recovery 
      following ischemic cerebral injury.
FAU - Sim, Young-Je
AU  - Sim YJ
AD  - Research Institute of Sports Science, Korea University, #15-Ka Anam-dong, 
      Sungbuk-ku, Seoul 136-701, Republic of Korea.
FAU - Kim, Sung-Soo
AU  - Kim SS
FAU - Kim, Jee-Youn
AU  - Kim JY
FAU - Shin, Mal-Soon
AU  - Shin MS
FAU - Kim, Chang-Ju
AU  - Kim CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspases)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Avoidance Learning/physiology
MH  - Brain Ischemia/*pathology
MH  - Bromodeoxyuridine
MH  - Caspase 3
MH  - Caspases/metabolism
MH  - Cell Proliferation
MH  - DNA Fragmentation
MH  - Dentate Gyrus/cytology/physiology
MH  - Gerbillinae
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Neurons/*pathology/*physiology
MH  - Physical Conditioning, Animal/*physiology
MH  - Physical Exertion/*physiology
EDAT- 2004/11/16 09:00
MHDA- 2005/01/06 09:00
CRDT- 2004/11/16 09:00
PHST- 2004/05/07 00:00 [received]
PHST- 2004/09/22 00:00 [revised]
PHST- 2004/09/22 00:00 [accepted]
PHST- 2004/11/16 09:00 [pubmed]
PHST- 2005/01/06 09:00 [medline]
PHST- 2004/11/16 09:00 [entrez]
AID - S0304-3940(04)01194-2 [pii]
AID - 10.1016/j.neulet.2004.09.060 [doi]
PST - ppublish
SO  - Neurosci Lett. 2004 Dec 6;372(3):256-61. doi: 10.1016/j.neulet.2004.09.060.